Department of Oncology, Southwest Hospital, Third Military Medical University, Chongqing, PR China.
DNA Cell Biol. 2012 Jun;31(6):1070-7. doi: 10.1089/dna.2011.1380. Epub 2012 Feb 17.
E-cadherin, encoded by the CDH1 gene, involves in invasion and metastasis of cancer cells. CDH1 -C160A polymorphism was shown to contribute to genetic susceptibility to colorectal cancer (CRC). However, the results from different studies remain controversial. This study was conducted to further explore the association between CDH1 -C160A genetic polymorphism and CRC susceptibility by means of a meta-analysis. A comprehensive literature search was conducted to identify all case-control studies of CDH1 -C160A polymorphism and risk for CRC. A total of nine eligible studies, including 7954 CRC cases and 7369 controls, were identified to the meta-analysis. On the whole, the meta-analysis indicated that CDH1 -C160A genetic polymorphism could reduce the risk of CRC under AA versus CC contrast (odds ratio [OR]=0.86, 95% confidence interval [CI]=0.75-0.98, p(heterogeneity)=0.11), recessive model (OR=0.88, 95% CI=0.77-0.99, p(heterogeneity)=0.23), dominant model (OR=0.92, 95% CI=0.87-0.99, p(heterogeneity)=0.11), and allele A versus allele C contrast (OR=0.93, 95% CI=0.88-0.98, p(heterogeneity)=0.26). A conclusion could be drawn from the research that CDH1 -C160A polymorphism provides a possible protection against CRC, which is especially evident in Caucasian and hospital populations.
E-钙黏蛋白由 CDH1 基因编码，参与癌细胞的侵袭和转移。CDH1-C160A 多态性被认为与结直肠癌（CRC）的遗传易感性有关。然而，来自不同研究的结果仍然存在争议。本研究通过荟萃分析进一步探讨了 CDH1-C160A 遗传多态性与 CRC 易感性的关系。进行了全面的文献检索，以确定所有关于 CDH1-C160A 多态性与 CRC 风险的病例对照研究。共有 9 项符合条件的研究，包括 7954 例 CRC 病例和 7369 例对照，被纳入荟萃分析。总的来说，荟萃分析表明，CDH1-C160A 遗传多态性在 AA 与 CC 对比（优势比[OR]=0.86，95%置信区间[CI]=0.75-0.98，p（异质性）=0.11）、隐性模型（OR=0.88，95% CI=0.77-0.99，p（异质性）=0.23）、显性模型（OR=0.92，95% CI=0.87-0.99，p（异质性）=0.11）和等位基因 A 与等位基因 C 对比（OR=0.93，95% CI=0.88-0.98，p（异质性）=0.26）中降低 CRC 的风险。从这项研究中可以得出结论，CDH1-C160A 多态性为 CRC 提供了一种可能的保护，这在白人和医院人群中尤为明显。
