Wang Wan-Fen, Shi Jun, Chen Shao-Juan, Niu Yu-Ming, Zeng Xian-Tao
Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, P.R. China.
Department of Stomatology, Shiyan Maternal and Child Health Hospital, Hubei University of Medicine, Shiyan, Hubei, P.R. China.
Biomed Rep. 2014 May;2(3):378-383. doi: 10.3892/br.2014.240. Epub 2014 Feb 19.
A number of published studies investigated the association between interleukin-1α (IL-1α) -899 (+4845) C→T polymorphism and susceptibility to aggressive periodontitis (AgP). However, the results from different studies are controversial. This study was conducted to further investigate the association between IL-1α -899 (+4845) C→T polymorphism and AgP using a meta-analysis. A search was conducted through PubMed up to May 1, 2013 and a total of 19 relevant case-control studies were identified. The results of this meta-analysis demonstrated that IL-1α -899 (+4845) C→T polymorphism is not associated with susceptibility to AgP under allele T vs. C [odds ratio (OR)=1.00, 95% confidence interval (CI): 0.88-1.14, P=0.98; I=28.86%] or allele A vs. C comparison (OR=0.99, 95% CI: 0.85-1.14, P=0.85; I=33.66%). The subgroup analyses based on ethnicity, source of controls and Hardy-Weinberg equilibrium (HWE) also revealed no such association. There existed a weak publication bias (Egger's test P=0.02). In conclusion, based on the currently available evidence, there is no association between IL-1α -899 (+4845) C→T polymorphism and susceptibility to AgP.
一些已发表的研究调查了白细胞介素-1α（IL-1α）-899（+4845）C→T多态性与侵袭性牙周炎（AgP）易感性之间的关联。然而，不同研究的结果存在争议。本研究通过荟萃分析进一步调查IL-1α -899（+4845）C→T多态性与AgP之间的关联。截至2013年5月1日通过PubMed进行了检索，共识别出19项相关的病例对照研究。该荟萃分析的结果表明，在等位基因T与C比较时[比值比（OR）=1.00，95%置信区间（CI）：0.88 - 1.14，P = 0.98；I² = 28.86%]或等位基因A与C比较时，IL-1α -899（+4845）C→T多态性与AgP易感性无关（OR = 0.99，95% CI：0.85 - 1.14，P = 0.85；I² = 33.66%）。基于种族、对照来源和哈迪 - 温伯格平衡（HWE）的亚组分析也未显示出这种关联。存在较弱的发表偏倚（Egger检验P = 0.02）。总之，基于目前可得的证据，IL-1α -899（+4845）C→T多态性与AgP易感性之间无关联。
