Gayle H D, Keeling R P, Garcia-Tunon M, Kilbourne B W, Narkunas J P, Ingram F R, Rogers M F, Curran J W
Division of HIV/AIDS, Centers for Disease Control, Atlanta, GA 30333.
N Engl J Med. 1990 Nov 29;323(22):1538-41. doi: 10.1056/NEJM199011293232206.
To estimate the magnitude of the human immunodeficiency virus (HIV) epidemic among university students, we conducted a blinded HIV-seroprevalence survey at 19 universities throughout the United States. HIV-antibody testing was performed on blood collected for routine medical purposes at the student health centers of the participating institutions. At each campus, from 250 to 1000 blood specimens were collected consecutively and tested for HIV antibodies by enzyme-linked immunosorbent assay and Western blot analysis. Nonidentifying demographic data were linked with the test results.
Of 16,863 specimens in the sample, 30 (0.2 percent) were positive for antibodies to HIV. Positive specimens were found at 9 of the 19 schools. All were from students over 18 years old; 19 (63 percent) were from students over 24. All but 2 of the 30 infected students were men. The seroprevalence rate for men was 0.5 percent (95 percent confidence interval, 0.3 to 0.7), and for women it was 0.02 percent (95 percent confidence interval, 0.002 to 0.066). Seroprevalence increased with age--from 0.08 percent (95 percent confidence interval, 0.04 to 0.15) for students 18 to 24 years old to 1.0 percent (95 percent confidence interval, 0.2 to 2.9) for those 40 or older.
HIV infection is present on U.S. university campuses, although the rate appears to be far lower than that of populations known to be at high risk. The potential clearly exists, however, for the further spread of HIV infection in this population, and preventive measures are needed.
为了评估美国大学生人群中人类免疫缺陷病毒(HIV)的流行程度,我们在美国19所大学开展了一项HIV血清流行率盲法调查。在参与机构的学生健康中心,对为常规医疗目的采集的血液进行HIV抗体检测。在每个校园,连续采集250至1000份血标本,并通过酶联免疫吸附试验和蛋白质印迹分析检测HIV抗体。将不具识别性的人口统计学数据与检测结果相联系。
在样本中的16863份标本中,30份(0.2%)HIV抗体呈阳性。在19所学校中的9所发现了阳性标本。所有阳性标本均来自18岁以上的学生;19份(63%)来自24岁以上的学生。30名感染学生中除2名外均为男性。男性血清流行率为0.5%(95%置信区间,0.3至0.7),女性为0.02%(95%置信区间,0.002至0.066)。血清流行率随年龄增长而升高——18至24岁学生为0.08%(95%置信区间,0.04至0.15),40岁及以上学生为1.0%(95%置信区间,0.2至2.9)。
HIV感染在美国大学校园中存在,尽管该感染率似乎远低于已知的高危人群。然而,HIV感染在这一人群中进一步传播的可能性显然存在,因此需要采取预防措施。