孟加拉国居民中 GSTO 和 AS3MT 基因多态性与尿砷浓度的差异。
GSTO and AS3MT genetic polymorphisms and differences in urinary arsenic concentrations among residents in Bangladesh.
机构信息
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
出版信息
Biomarkers. 2012 May;17(3):240-7. doi: 10.3109/1354750X.2012.658863. Epub 2012 Feb 18.
Abstract
We determined whether single nucleotide polymorphisms (SNPs) in the glutathione S-transferase omega (GSTO) and arsenic(III)methyltransferase (AS3MT) genes were associated with concentrations of urinary arsenic metabolites among 900 individuals without skin lesions in Bangladesh. Four SNPs were assessed in these genes. A pathway analysis evaluated the association between urinary arsenic metabolites and SNPs. GSTO1 rs4925 homozygous wild type was significantly associated with higher monomethylarsonic acid (MMA) and dimethylarsinic acid urinary concentrations, whereas wild-type AS3MT rs11191439 had significantly lower levels of As(III) and MMA. Genetic polymorphisms GSTO and As3MT modify arsenic metabolism as evidenced by altered urinary arsenic excretion.
摘要
我们在孟加拉国 900 名无皮肤损伤的个体中，确定了谷胱甘肽 S-转移酶 ω（GSTO）和砷（III）甲基转移酶（AS3MT）基因中的单核苷酸多态性（SNPs）是否与尿砷代谢物浓度相关。在这些基因中评估了四个 SNPs。通路分析评估了尿砷代谢物与 SNPs 之间的关联。GSTO1 rs4925 纯合野生型与较高的单甲基砷酸（MMA）和二甲基砷酸尿浓度显著相关，而野生型 AS3MT rs11191439 具有显著较低的 As(III)和 MMA 水平。遗传多态性 GSTO 和 As3MT 可改变砷代谢，这可通过改变尿砷排泄来证明。
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