Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Biochemistry (Mosc). 2011 Dec;76(13):1402-33. doi: 10.1134/S0006297911130049.
This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the participation of YB-1 in DNA reparation and transcription, mRNA splicing and translation are systematized. Results on interactions of YB-1 with cytoskeleton components and its possible role in mRNA localization are discussed. Data on intracellular distribution of YB-1, its redistribution between the nucleus and the cytoplasm, and its secretion and extracellular functions are summarized. The effect of YB-1 on cell differentiation, its involvement in extra- and intracellular signaling pathways, and its role in early embryogenesis are described. The mechanisms of regulation of YB-1 expression in the cell are presented. Special attention is paid to the involvement of YB-1 in oncogenic cell transformation, multiple drug resistance, and dissemination of tumors. Both the oncogenic and antioncogenic activities of YB-1 are reviewed. The potential use of YB-1 in diagnostics and therapy as an early cancer marker and a molecular target is discussed.
本文综述了 Y 盒结合蛋白 1（YB-1）及其同源物的结构和功能。讨论了 YB-1 与 DNA、mRNA 和蛋白质的相互作用。系统整理了 YB-1 参与 DNA 修复和转录、mRNA 剪接和翻译的数据。讨论了 YB-1 与细胞骨架成分的相互作用及其在 mRNA 定位中的可能作用。总结了 YB-1 在细胞内的分布、在核质间的重新分布及其分泌和细胞外功能。描述了 YB-1 对细胞分化的影响、参与细胞外和细胞内信号通路及其在早期胚胎发生中的作用。介绍了 YB-1 表达在细胞中的调控机制。特别关注 YB-1 在致癌性细胞转化、多药耐药和肿瘤播散中的作用。综述了 YB-1 的致癌和抑癌活性。讨论了 YB-1 作为早期癌症标志物和分子靶点在诊断和治疗中的潜在用途。
