Zhang Wenze, Liu Ying, Zhao Zhe, Zhang Yizhi, Liang Yujuan, Wang Wanxia
The First College of Clinical Medicine, Lanzhou University, Lanzhou 730000, China.
The First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China.
Curr Issues Mol Biol. 2024 Dec 13;46(12):14058-14079. doi: 10.3390/cimb46120841.
The Y-box binding protein 1 (YBX1) is a multifunctional protein with a wide range of roles in cell biology. It plays a crucial role in immune modulation, senescence, and disease progression. This review presents a comprehensive analysis of the specific functions and mechanisms of YBX1 in these areas. Initially, YBX1 is shown to be closely associated with cellular senescence and impacts significant biological processes, including cell proliferation, damage repair, and metabolism. This suggests potential applications in the prevention and treatment of senescence-related diseases. Additionally, YBX1 regulates the immune response by controlling the function of immune cells and the expression of immune molecules. It is essential in maintaining immune system homeostasis and impacts the pathological process of various diseases, including tumors. Lastly, the diverse functions of the YBX1 protein make it a promising candidate for the development of innovative therapeutic strategies for diseases. Comprehensive research on its mechanisms could provide novel insights and approaches for the prevention, diagnosis, and treatment of related diseases.
Y盒结合蛋白1（YBX1）是一种多功能蛋白，在细胞生物学中具有广泛作用。它在免疫调节、衰老和疾病进展中发挥关键作用。本综述对YBX1在这些领域的具体功能和机制进行了全面分析。最初，YBX1被证明与细胞衰老密切相关，并影响包括细胞增殖、损伤修复和代谢在内的重要生物学过程。这表明其在衰老相关疾病的预防和治疗中具有潜在应用。此外，YBX1通过控制免疫细胞功能和免疫分子表达来调节免疫反应。它对维持免疫系统稳态至关重要，并影响包括肿瘤在内的各种疾病的病理过程。最后，YBX1蛋白的多种功能使其成为开发疾病创新治疗策略的有前景的候选者。对其机制的全面研究可为相关疾病的预防、诊断和治疗提供新的见解和方法。
