NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, UK.
Clin Exp Ophthalmol. 2012 May-Jun;40(4):369-80. doi: 10.1111/j.1442-9071.2012.02770.x. Epub 2012 Apr 12.
An understanding of the relationship between functional and structural measures in primary open-angle glaucoma is necessary for both grading the severity of disease and for understanding the natural history of the condition. This article outlines the current evidence for the nature of this relationship and highlights the current mathematical models linking structure and function. Large clinical trials demonstrate that both structural and functional change are apparent in advanced stages of disease, and at an individual level, detectable structural abnormality may precede functional abnormality in some patients, whereas the converse is true in other patients. Although the exact nature of the 'structure-function' relationship in primary open-angle glaucoma is still the topic of scientific debate and the subject of continuing research, this article aims to provide the clinician with an understanding of the past concepts and contemporary thinking in relation to the structure-function relationship in primary open-angle glaucoma.
了解原发性开角型青光眼的功能和结构测量之间的关系，对于评估疾病的严重程度和了解疾病的自然病程都是必要的。本文概述了目前关于这种关系的本质的证据，并强调了目前将结构和功能联系起来的数学模型。大型临床试验表明，在疾病的晚期，结构和功能都发生了变化，在个体水平上，一些患者的结构异常可能先于功能异常，而在其他患者中则相反。尽管原发性开角型青光眼的“结构-功能”关系的确切性质仍然是科学争论的主题，也是持续研究的主题，但本文旨在为临床医生提供对原发性开角型青光眼结构-功能关系的过去概念和当代思维的理解。
