Department of Radiation Oncology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
Radiat Oncol. 2012 Feb 16;7:22. doi: 10.1186/1748-717X-7-22.
The purpose of this study was to evaluate acute and late toxicities of radiotherapy for patients with discoid lupus erythematosus (DLE).
A retrospective review was performed of patients with DLE who received radiotherapy at our institution between 1980 and 2005. Patients with other connective tissue disorders were excluded. Control patients were matched 2:1 with the DLE treatment courses based on age, cancer diagnosis, year of treatment, radiotherapy dose, and sex. Acute (within 30 days from the completion of radiotherapy) and late toxicities were evaluated for each treatment course using the Common Terminology Criteria for Adverse Events Version 3.0.
Twelve patients with DLE received a total of 15 radiotherapy courses. The median follow-up time was 2.6 years (range, 0.0-15.2 years). Acute toxicity of any organ was observed in 10 (67%) treatment courses, of which 2 (13%) were Grade 3 or higher. Acute Grade 1 or 2 dermatologic toxicity was observed in 8 courses (53%). Late toxicity of any organ was observed in 7 of 12 (58%) evaluable treatment courses, of which 3 (23%) were grade 3 or higher. Late grade 1 or 2 dermatologic toxicity was observed in 5 (42%) courses. No patient experienced acute or late Grade 3 or higher dermatologic toxicity. The rates of any organ or dermatologic acute and late toxicity were not significantly different between DLE and control treatment courses.
Our findings do not suggest an increased risk of toxicity to the skin or other organs in patients with DLE receiving radiotherapy.
本研究旨在评估盘状红斑狼疮（DLE）患者接受放射治疗的急性和晚期毒性。
回顾性分析了 1980 年至 2005 年期间在我院接受放射治疗的 DLE 患者。排除了其他结缔组织疾病患者。根据年龄、癌症诊断、治疗年份、放射剂量和性别，将对照组患者与 DLE 治疗课程以 2:1 的比例匹配。使用不良事件通用术语标准 3.0 版评估每个治疗课程的急性（放射治疗完成后 30 天内）和晚期毒性。
12 例 DLE 患者共接受 15 次放射治疗课程。中位随访时间为 2.6 年（范围 0.0-15.2 年）。10 次（67%）治疗课程观察到任何器官的急性毒性，其中 2 次（13%）为 3 级或更高。8 次（53%）课程观察到急性 1 级或 2 级皮肤毒性。12 次可评估治疗课程中有 7 次（58%）观察到任何器官的晚期毒性，其中 3 次（23%）为 3 级或更高。5 次（42%）课程观察到晚期 1 级或 2 级皮肤毒性。没有患者发生急性或晚期 3 级或更高的皮肤毒性。DLE 和对照组治疗课程的皮肤或其他器官急性和晚期毒性的发生率无显著差异。
我们的研究结果并未提示接受放射治疗的 DLE 患者皮肤或其他器官发生毒性的风险增加。
