Kang P J, Ostermann J, Shilling J, Neupert W, Craig E A, Pfanner N
Department of Physiological Chemistry, University of Wisconsin, Madison 53706.
Nature. 1990 Nov 8;348(6297):137-43. doi: 10.1038/348137a0.
By analysis of a temperature-sensitive yeast mutant, a heat-shock protein in the matrix of mitochondria, mitochondrial hsp70 (Ssc1p), is found to be involved both in translocation of nuclear-encoded precursor proteins across the mitochondrial membranes and in (re)folding of imported proteins in the matrix.
通过对一种温度敏感型酵母突变体的分析，发现线粒体基质中的一种热休克蛋白——线粒体hsp70（Ssc1p），既参与核编码前体蛋白穿过线粒体膜的转运过程，又参与基质中输入蛋白的（再）折叠过程。
