Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK.
Vet J. 2012 Aug;193(2):586-8. doi: 10.1016/j.tvjl.2012.01.008. Epub 2012 Feb 16.
Bovine abortion represents a major animal welfare issue and a cause of substantial economic loss yet the rate of successful diagnosis remains low. Chlamydia-related organisms including Parachlamydia have recently emerged as putative cattle abortifacients. Placental tissue samples and fetal lung from bovine abortion submissions across Scotland in Spring 2011 were investigated by histopathology for the presence of suspect Chlamydia-related organisms. Evidence of Chlamydia-related organisms was observed in 21/113 (18.6%) placenta samples. Thirteen of the suspect cases and 18 histopathology negative cases were analysed by molecular and immunohistochemical methods. All samples were PCR positive for Parachlamydia but sequencing revealed high homology between identified environmental 16S sequences in all but three cases. Parachlamydial antigen was detected in 10/31 placental samples (32.2%) with pathology consistent with chlamydial infection. This work supports the need for further surveillance investigations and experimental studies to determine the role of Parachlamydia in bovine abortion.
牛流产是一个主要的动物福利问题，也是造成重大经济损失的原因，但诊断的成功率仍然很低。最近，衣原体相关生物，包括副衣原体，被认为是牛流产的原因。2011 年春季，苏格兰各地的流产牛提交的胎盘组织样本和胎儿肺组织通过组织病理学检查是否存在可疑的衣原体相关生物。在 113 个胎盘样本中，有 21 个（18.6%）观察到疑似衣原体相关生物的证据。对 13 个可疑病例和 18 个组织病理学阴性病例进行了分子和免疫组织化学分析。所有样本的 PCR 均为副衣原体阳性，但测序结果显示，除了三个病例外，所有病例的鉴定环境 16S 序列高度同源。在 10/31 个胎盘样本（32.2%）中检测到副衣原体抗原，其病理学与衣原体感染一致。这项工作支持进一步进行监测调查和实验研究，以确定副衣原体在牛流产中的作用。
