Department of Preventive Medicine and Public Health, Faculty of Veterinary Medicine, University of Khartoum, Khartoum North, PO Box 32, Sudan.
Prev Vet Med. 2012 Jun 1;105(1-2):1-9. doi: 10.1016/j.prevetmed.2012.01.004. Epub 2012 Feb 16.
Bovine farcy (which is caused by Mycobacterium farcinogenes and Mycobacterium senegalense) is a chronic suppurative granulomatous inflammation of the skin and lymphatics of cattle and is seen mostly in sub-Saharan Africa. It is not yet certain whether Nocardia farcinica causes cutaneous nocardiosis (farcy) in animals that mimics bovine farcy. Epidemiological data have steadily reported finding bovine farcy in adult cattle of the transhumance pastoralist tribes of the Sahel and the Sudanian savannah zones. M. farcinogenes and or M. senegalense do not affect other domestic or non-domestic animals; it is not known whether these bacteria are zoonotic. The disease--once widespread in many regions--has disappeared from some countries historically known to have it. Reports of bovine farcy prevalence seem to be linked to the existence of survey initiatives by governments and diagnostic capabilities in each country. Farcy causes economic loss due to damaged hides and also is a public-health burden (because the lymphadenitis due to farcy resembles the lesions of bovine tuberculosis in carcasses and the meat is considered inappropriate for human consumption). The current literature is deficient in establishing definitely the prevalence, transmission patterns, and risk factors of bovine farcy. Ixodid ticks transmit other skin diseases (such as dermatophilosis) and might play a role in bovine farcy (given the similarity in the bio-physiology and geographic distribution of the disease). In addition, the tick-resistance of cattle breeds such as the N'Dama, Fulani or the Nilotic might explain their resistance to bovine farcy. Apart from the judicious use of conventional smear-and-culture methods, few diagnostic tests have been developed; the molecular and serological tests have not been evaluated for reproducibility and accuracy. This review points out aspects of bovine farcy that need further research and updates available data on the prevalence, distribution, risk factors, economic and public health implications, diagnosis, and control.
牛类痈(由化脓隐秘杆菌和非洲分枝杆菌引起)是一种牛的皮肤和淋巴管的慢性化脓性肉芽肿性炎症,主要见于撒哈拉以南非洲。目前还不确定诺卡氏菌是否会引起动物的皮肤诺卡氏病(痈),这种病类似于牛类痈。流行病学数据不断报告在萨赫勒和苏丹稀树草原带的游牧牧民部落的成年牛中发现牛类痈。化脓隐秘杆菌和/或非洲分枝杆菌不会影响其他家畜或非家畜;这些细菌是否人畜共患还不清楚。这种疾病曾在许多地区广泛流行,但在一些历史上有该病的国家已经消失。牛类痈的流行报告似乎与各国政府的调查倡议和诊断能力的存在有关。痈会导致皮革受损,造成经济损失,同时也是公共卫生的负担(因为痈引起的淋巴结炎与牛结核病在尸体上的病变相似,因此被认为不适合人类食用)。目前的文献在确定牛类痈的流行率、传播模式和风险因素方面存在不足。硬蜱传播其他皮肤疾病(如丹毒),并可能在牛类痈中发挥作用(鉴于该病的生物生理学和地理分布相似)。此外,像 N'Dama、富拉尼或尼罗特这样的牛品种对硬蜱的抵抗力可能解释了它们对牛类痈的抵抗力。除了明智地使用传统的涂片和培养方法外,很少有诊断测试被开发出来;分子和血清学测试的重现性和准确性尚未得到评估。这篇综述指出了牛类痈需要进一步研究的方面,并更新了该病的流行率、分布、风险因素、经济和公共卫生影响、诊断和控制方面的现有数据。