Sen U, Guha S
Chittaranjan National Cancer Research Centre, Calcutta, India.
Neoplasma. 1990;37(5):521-6.
The pattern of changes in the polyamine spectrum has been studied under the stress of Sarcoma 180, a transplanted tumor growing in the peritoneal cavity of mice. Retinol, a known inhibitor of ornithine decarboxylase, was used to modulate tumor growth pattern and subsequent changes in the level of polyamines. The polyamine levels showed an increase during tumor proliferation. In the treated group, however, the enhanced levels exhibited a tendency to decrease, along with tumor inhibition, indicating that a positive correlation exists between the polyamine content in the red blood cells of mice and the tumor growth pattern.
在小鼠腹腔内生长的移植性肿瘤肉瘤180的应激条件下，研究了多胺谱的变化模式。视黄醇是一种已知的鸟氨酸脱羧酶抑制剂，用于调节肿瘤生长模式以及随后多胺水平的变化。在肿瘤增殖过程中，多胺水平呈现升高。然而，在治疗组中，随着肿瘤受到抑制，升高的多胺水平呈现出下降趋势，这表明小鼠红细胞中的多胺含量与肿瘤生长模式之间存在正相关。
