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1
p85α SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation.
Mol Cell. 2012 Mar 30;45(6):719-30. doi: 10.1016/j.molcel.2012.01.010. Epub 2012 Feb 16.
3
Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IκB signaling pathways.
Eur J Pharmacol. 2011 Jan 10;650(1):102-9. doi: 10.1016/j.ejphar.2010.10.004. Epub 2010 Oct 14.
5
IKK-dependent, NF-κB-independent control of autophagic gene expression.
Oncogene. 2011 Apr 7;30(14):1727-32. doi: 10.1038/onc.2010.553. Epub 2010 Dec 13.
6
Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains.
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14157-62. doi: 10.1073/pnas.1107747108. Epub 2011 Aug 8.
7
Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase.
J Biol Chem. 2001 Jul 20;276(29):27455-61. doi: 10.1074/jbc.M100556200. Epub 2001 May 3.

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The role of SUMOylation in epithelial-mesenchymal transition.
J Mol Med (Berl). 2025 Sep;103(9):1005-1018. doi: 10.1007/s00109-025-02568-3. Epub 2025 Jul 4.
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Natural saponins and macrophage polarization: Mechanistic insights and therapeutic perspectives in disease management.
Front Pharmacol. 2025 May 9;16:1584035. doi: 10.3389/fphar.2025.1584035. eCollection 2025.
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Divergent roles of the regulatory subunits of class IA PI3K.
Front Endocrinol (Lausanne). 2024 Jan 22;14:1152579. doi: 10.3389/fendo.2023.1152579. eCollection 2023.
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Phosphorylation at tyrosine 317 and 508 are crucial for PIK3CA/p110α to promote CRC tumorigenesis.
Cell Biosci. 2023 Sep 9;13(1):164. doi: 10.1186/s13578-023-01102-7.
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Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model.
Protein Cell. 2021 Oct;12(10):769-787. doi: 10.1007/s13238-021-00858-3. Epub 2021 Jul 21.
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Epigenetic regulation of autophagy: A key modification in cancer cells and cancer stem cells.
World J Stem Cells. 2021 Jun 26;13(6):542-567. doi: 10.4252/wjsc.v13.i6.542.
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Lights and Shade of Next-Generation Pi3k Inhibitors in Chronic Lymphocytic Leukemia.
Onco Targets Ther. 2020 Sep 29;13:9679-9688. doi: 10.2147/OTT.S268899. eCollection 2020.

本文引用的文献

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AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function.
Genes Dev. 2011 Sep 15;25(18):1895-908. doi: 10.1101/gad.17420111.
2
Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains.
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14157-62. doi: 10.1073/pnas.1107747108. Epub 2011 Aug 8.
3
NF-κB, inflammation, and metabolic disease.
Cell Metab. 2011 Jan 5;13(1):11-22. doi: 10.1016/j.cmet.2010.12.008.
4
IKK-dependent, NF-κB-independent control of autophagic gene expression.
Oncogene. 2011 Apr 7;30(14):1727-32. doi: 10.1038/onc.2010.553. Epub 2010 Dec 13.
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Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress.
Mol Cell. 2010 Oct 22;40(2):310-22. doi: 10.1016/j.molcel.2010.09.026.
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The IKK complex contributes to the induction of autophagy.
EMBO J. 2010 Feb 3;29(3):619-31. doi: 10.1038/emboj.2009.364. Epub 2009 Dec 3.
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Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants.
Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20258-63. doi: 10.1073/pnas.0902369106. Epub 2009 Nov 13.
8
The protein kinase IKKepsilon regulates energy balance in obese mice.
Cell. 2009 Sep 4;138(5):961-75. doi: 10.1016/j.cell.2009.06.046.
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Regulation mechanisms and signaling pathways of autophagy.
Annu Rev Genet. 2009;43:67-93. doi: 10.1146/annurev-genet-102808-114910.
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Glutamine attenuates inflammation and NF-kappaB activation via Cullin-1 deneddylation.
Biochem Biophys Res Commun. 2008 Aug 29;373(3):445-9. doi: 10.1016/j.bbrc.2008.06.057. Epub 2008 Jun 25.

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