University of Bath, Department of Pharmacy and Pharmacology, Claverton Down, Bath, BA2 7AY, UK.
J Control Release. 2012 Jul 20;161(2):247-53. doi: 10.1016/j.jconrel.2012.01.017. Epub 2012 Feb 11.
The oral delivery of drugs is considered by decision-makers in the pharmaceutical industry to be the most appealing route of administration. This belief has led to the identification of many very successful drugs, but also to the downfall of some promising therapeutics that failed to meet criteria required for sufficient oral bioavailability. Efforts to correct these deficiencies have led to a plethora of creative strategies to overcome the physical, chemical, and biological barriers that limit the efficient and consistent delivery of drugs that are not readily absorbed following oral administration. The goal of this perspective is to describe these barriers to oral drug delivery in relation to some of the work currently being undertaken by the community of European scientists. This perspective is not intended to be inclusive and the author apologizes in advance to the many scientists working in Europe whose recent work was not included.
药物的口服给药被制药行业的决策者认为是最具吸引力的给药途径。这种信念导致了许多非常成功的药物的出现，但也导致了一些有前途的治疗方法的失败，这些治疗方法未能达到足够口服生物利用度的标准。为了纠正这些缺陷，人们已经提出了许多富有创意的策略来克服限制口服给药后不易吸收的药物有效和一致传递的物理、化学和生物学障碍。本文的目的是描述这些口服药物输送的障碍，以及目前欧洲科学界正在进行的一些工作。本文无意包罗万象，作者向许多在欧洲工作的科学家表示歉意，他们最近的工作没有被包括在内。
