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用于界面药物传递的变革性材料。

Transformative Materials for Interfacial Drug Delivery.

机构信息

Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074, Aachen, Germany.

Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIOABCD), 52074, Aachen, Germany.

出版信息

Adv Healthc Mater. 2023 Aug;12(20):e2301062. doi: 10.1002/adhm.202301062. Epub 2023 Jun 6.

DOI:10.1002/adhm.202301062
PMID:37282805
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11468550/
Abstract

Drug delivery systems (DDS) are designed to temporally and spatially control drug availability and activity. They assist in improving the balance between on-target therapeutic efficacy and off-target toxic side effects. DDS aid in overcoming biological barriers encountered by drug molecules upon applying them via various routes of administration. They are furthermore increasingly explored for modulating the interface between implanted (bio)medical materials and host tissue. Herein, an overview of the biological barriers and host-material interfaces encountered by DDS upon oral, intravenous, and local administration is provided, and material engineering advances at different time and space scales to exemplify how current and future DDS can contribute to improved disease treatment are highlighted.

摘要

药物传递系统（DDS）旨在对药物的释放和活性进行时空控制。它们有助于改善靶治疗疗效与非靶毒性副作用之间的平衡。DDS 有助于克服药物分子通过各种给药途径应用时遇到的生物屏障。此外，它们还越来越多地被用于调节植入（生物）医学材料与宿主组织之间的界面。本文概述了 DDS 在口服、静脉内和局部给药时遇到的生物屏障和宿主材料界面，并介绍了不同时间和空间尺度上的材料工程进展，以说明当前和未来的 DDS 如何有助于改善疾病治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/383b/11468550/d78b27636339/ADHM-12-2301062-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/383b/11468550/a58646ecb86e/ADHM-12-2301062-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/383b/11468550/fefcc082b3d8/ADHM-12-2301062-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/383b/11468550/0b755fe3116e/ADHM-12-2301062-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/383b/11468550/d78b27636339/ADHM-12-2301062-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/383b/11468550/a58646ecb86e/ADHM-12-2301062-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/383b/11468550/fefcc082b3d8/ADHM-12-2301062-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/383b/11468550/0b755fe3116e/ADHM-12-2301062-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/383b/11468550/d78b27636339/ADHM-12-2301062-g002.jpg

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