Department of Medicine, Dentistry & Health Sciences, University of Melbourne, Grattan Street, Parkville, VIC 3050, Australia.
Breast. 2012 Jun;21(3):314-20. doi: 10.1016/j.breast.2012.01.013. Epub 2012 Feb 17.
The objective of this study was to examine factors impacting long-term functional outcomes and psychological sequelae in survivors of breast cancer (BC). A clinical assessment and structured interview assessed the impact of BC on participants' (n=85) current activity and restriction in participation, using validated questionnaires: Functional Independence Measure (FIM), Perceived Impact Problem Profile (PIPP) and Depression Anxiety Stress Scale (DASS). Participants showed good functional recovery (median motor FIM score=78). Three-quarters (74%) reported pain, 32% reported upper limb weakness, 31% pain limiting shoulder movement and 29% lymphoedema. One third (32%) reported greatest impact on psychological wellbeing. A substantial number of participants reported high levels of depression (22%), anxiety and stress (19% each). Factors associated with poorer current level of functioning and wellbeing included: younger participants, recent diagnoses, aggressive tumour types, receiving chemotherapy, shoulder limitation due to pain, and lymphoedema. BC survivors require long-term management of psychological sequelae impacting activity and participation.
本研究旨在探讨影响乳腺癌（BC）幸存者长期功能结局和心理后遗症的因素。通过临床评估和结构化访谈，使用经过验证的问卷（功能独立性测量量表（FIM）、感知影响问题量表（PIPP）和抑郁焦虑压力量表（DASS））评估 BC 对参与者（n=85）当前活动和参与受限的影响。参与者表现出良好的功能恢复（中位数运动 FIM 评分为 78）。75%的人报告有疼痛，32%的人报告上肢无力，31%的人报告疼痛限制肩部运动，29%的人报告淋巴水肿。三分之一（32%）的人报告对心理健康的影响最大。相当一部分参与者报告存在较高水平的抑郁（22%）、焦虑和压力（各 19%）。与当前功能水平和健康状况较差相关的因素包括：年龄较小、近期诊断、侵袭性肿瘤类型、接受化疗、因疼痛导致肩部受限以及淋巴水肿。BC 幸存者需要长期管理影响活动和参与的心理后遗症。
