Kang Sok-Leng, Tometzki Andrew, Taliotis Demetris, Martin Robin
Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Paul O'Gorman Building, Upper Maudlin Street, Bristol, BS2 8BJ, UK.
Pediatr Cardiol. 2017 Oct;38(7):1441-1449. doi: 10.1007/s00246-017-1682-x. Epub 2017 Aug 5.
To report our experience of coarctation stent therapy in small children weighing less than 30 kg, with the low profile dilatable Valeo stent and review the literature on coarctation stent therapy in this patient population. Coarctation stent implantation was undertaken in 14 consecutive children using the Bard Valeo Stent. Demographic, angiographic, echocardiographic and clinical data were reviewed retrospectively. The median age at the time of procedure was 5.1 (2.6-7.5) years and median weight was 20.8 (14.7-27) kg. There was improvement in median coarctation diameter from 4 (1.3-5.2) to 9.5 (5.8-12.7) mm, p < 0.001; and a reduction in the median peak pressure gradient across the coarctation from 35 (20-49) to 9 (0-15) mmHg, p < 0.001. Median stent recoil was 7.9 (0-20)%. There was one case of access related complication that resolved without sequelae. Follow-up was a median of 15 (3.0-57.2) months. CT angiogram performed at a median time of 3.3 (2.6-10.2) months post procedure showed no aortic wall injury and preserved stent integrity in all cases. Two children underwent re-intervention for stent dilation and further stent implantation due to in-stent stenosis and somatic growth after 3 years. Six of fourteen children remained on a single antihypertensive agent post-intervention at last follow-up. Implantation of the dilatable Valeo stent is a feasible treatment strategy in native or recurrent coarctation in small children, accepting that additional stent implantation may be necessary with somatic growth. Further study is required to determine longer-term stent efficacy and clinical outcome.
报告我们使用低轮廓可扩张的Valeo支架对体重小于30公斤的小儿进行缩窄支架治疗的经验,并回顾该患者群体缩窄支架治疗的相关文献。连续14例儿童使用Bard Valeo支架进行缩窄支架植入。回顾性分析人口统计学、血管造影、超声心动图和临床数据。手术时的中位年龄为5.1(2.6 - 7.5)岁,中位体重为20.8(14.7 - 27)公斤。缩窄处的中位直径从4(1.3 - 5.2)毫米改善至9.5(5.8 - 12.7)毫米,p < 0.001;缩窄处的中位峰值压力梯度从35(20 - 49)毫米汞柱降至9(0 - 15)毫米汞柱,p < 0.001。支架中位回缩率为7.9(0 - 20)%。有1例与穿刺相关的并发症,未遗留后遗症而自行缓解。随访时间中位数为15(3.0 - 57.2)个月。术后中位时间3.3(2.6 - 10.2)个月进行的CT血管造影显示,所有病例均无主动脉壁损伤且支架完整性良好。3年后,2例儿童因支架内狭窄和身体生长接受了再次干预,进行支架扩张和进一步的支架植入。在最后一次随访时,14例儿童中有6例在干预后仍需服用单一降压药。对于小儿原发性或复发性缩窄,植入可扩张的Valeo支架是一种可行的治疗策略,但需认识到随着身体生长可能需要额外植入支架。需要进一步研究以确定支架的长期疗效和临床结局。