Attyé A, Boncoeur-Martel M-P, Maubon A, Mounayer C, Couratier P, Labrunie A, Le Bas J-F
CHU de Limoges, Neuroradiology-Radiology Department, 87000 Limoges, France.
J Neuroradiol. 2012 May;39(2):97-103. doi: 10.1016/j.neurad.2012.01.001. Epub 2012 Feb 18.
This study's purpose was to demonstrate a relationship between growth of stroke volume measured on Diffusion-Weighted MRI (DWI) at admission (baseline) and 24 hours later (follow-up) and functional outcome at 90 days evaluated by the modified Rankin Scale (mRS).
DWI infarct volumes were calculated, using an Analyze Software. Clinical outcomes were assessed at 90 days by the mRS. Univariate regression analysis was performed to assess the relationship between changes in DWI lesion volume and mRS less or equal to 1.
Sixty-nine cases had serial DWI scans with a measurable lesion at baseline and follow-up. The median baseline National Institutes of Health Stroke Scale (NIHSS) was 10, 5 and 7 at 24 hours. At 90 days, the proportion of patients with Rankin less or equal to 1 was 51.7%. The average baseline volume was 19.7 cm(3) and average follow-up volume was 46.1 cm(3). For each 10 cm(3) of growth in DWI infarct volume, the odds ratio for a mRS less or equal to 1 was 10,1 (IC 95%, 3-33.9).
The results of this study provide evidence of a significant inverse relationship between infarct growth measured by DWI and good functional clinical outcome at 90 days.
本研究的目的是证明入院时（基线）及24小时后（随访）通过弥散加权磁共振成像（DWI）测量的卒中体积增长与90天时通过改良Rankin量表（mRS）评估的功能结局之间的关系。
使用Analyze软件计算DWI梗死体积。在90天时通过mRS评估临床结局。进行单因素回归分析以评估DWI病变体积变化与mRS小于或等于1之间的关系。
69例患者在基线和随访时有连续的DWI扫描且有可测量的病变。基线时美国国立卫生研究院卒中量表（NIHSS）中位数为10，24小时时为5和7。在90天时，Rankin小于或等于1的患者比例为51.7%。基线平均体积为19.7 cm³，随访平均体积为46.1 cm³。DWI梗死体积每增长10 cm³，mRS小于或等于1的比值比为10.1（95%置信区间，3 - 33.9）。
本研究结果提供了证据，表明通过DWI测量的梗死增长与90天时良好的临床功能结局之间存在显著的负相关关系。
