Great Lakes Neurosurgical Associates, Grand Rapids, MI, USA.
J Neurosci Methods. 2012 Apr 30;206(1):34-9. doi: 10.1016/j.jneumeth.2012.02.002. Epub 2012 Feb 11.
Microelectrode recording (MER) is an important navigational and investigational tool, specifically with regard to deep brain stimulation (DBS) surgery. MER is often utilized when targeting the subthalamic nucleus (STN) and other deep brain nuclei in the management of Parkinson's disease (PD), tremor, dystonia and other emerging applications. Microelectrodes are used to detect and measure cellular spiking activity while macroelectrodes are considered more suitable for measuring the collective sum of slow potentials from multiple cells near the electrode, the local field potential (LFP). Precisely how the characteristics of an electrode affect the data recorded is still unclear. Technical idiosyncrasies of some surgical cases allowed serendipitous data collection from a 250 to 6000 Hz bandpassed macroelectrode recording during DBS implantation for PD. Simultaneous recording from both a microelectrode and macroelectrode were compared along the same surgical trajectory. Audio, normalized root mean square of the recorded signal, and power spectrograms were used to analyze the data. The analyses demonstrate similar results in detecting cellular spiking activity when recording with macroelectrodes compared with microelectrodes. This has important implications for the standardization of recording electrophysiological data as well as for the development of next generation closed-loop deep brain stimulation systems.
微电极记录 (MER) 是一种重要的导航和研究工具，特别是在深部脑刺激 (DBS) 手术中。在帕金森病 (PD)、震颤、肌张力障碍和其他新兴应用的管理中，当靶向丘脑底核 (STN) 和其他深部脑核时，通常会使用 MER。微电极用于检测和测量细胞尖峰活动，而宏观电极则更适合测量电极附近多个细胞的慢电位的总和，即局部场电位 (LFP)。电极的特性如何影响记录的数据仍然不清楚。一些手术病例的技术特点允许在 PD 的 DBS 植入过程中，从一个 250 到 6000 Hz 的带通宏观电极记录中偶然收集数据。同时在相同的手术轨迹上比较了微电极和宏观电极的记录。使用音频、记录信号的归一化均方根和功率频谱图来分析数据。分析表明，使用宏观电极记录时，在检测细胞尖峰活动方面与微电极具有相似的结果。这对记录电生理数据的标准化以及下一代闭环深部脑刺激系统的发展都具有重要意义。
