Cancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain.
Drug Discov Today. 2012 Jul;17(13-14):702-9. doi: 10.1016/j.drudis.2012.02.001. Epub 2012 Feb 10.
The presence of sufficient skeletal muscle mass is of paramount importance for body function and the myostatin cascade is known to inhibit muscle growth in mammals. In addition, myostatin seems to have an important role in the cross-talk between skeletal muscle and adipose tissue and is involved in insulin sensitivity. In this article we highlight the latest developments related to the myostatin system, emphasizing therapeutic implications for wasting diseases and also the involvement of the system in other organs, in addition to skeletal muscle, such as heart or adipose tissue. Moreover, we highlight the possible role of the myostatin system in the cross-talk between skeletal muscle and adipose tissue, an important aspect that deserves consideration in wasting diseases.
骨骼肌量的存在对身体功能至关重要，肌肉生长抑制素级联反应已知可抑制哺乳动物的肌肉生长。此外，肌肉生长抑制素似乎在骨骼肌和脂肪组织之间的交流中发挥着重要作用，并与胰岛素敏感性有关。在本文中，我们重点介绍了与肌肉生长抑制素系统相关的最新进展，强调了该系统在消耗性疾病治疗方面的意义，还介绍了该系统在心脏或脂肪组织等除骨骼肌以外的其他器官中的作用。此外，我们还强调了肌肉生长抑制素系统在骨骼肌和脂肪组织之间交流中的可能作用，这是消耗性疾病中值得关注的一个重要方面。
