Brinker T, Seifert V, Stolke D
Neurosurgical Clinic, Medical School Hannover, Federal Republic of Germany.
Neurosurgery. 1990 Sep;27(3):369-72. doi: 10.1097/00006123-199009000-00005.
Early changes in intracranial pressure (ICP), ICP volume index, and resistance to absorption of cerebrospinal fluid induced by experimental subarachnoid hemorrhage were studied in cats. After SAH, the ICP was slightly elevated, and there was a decrease in the buffering capacity of the intracranial space and a sharp rise in outflow resistance. During infusion of blood into the cisterna magna with a constant infusion rate, an extensive increase in ICP could be demonstrated in contrast to the infusion of saline, which caused only slight elevation of ICP. Furthermore, during blood infusion, the ICP level did not reach a plateau phase of pressure, as was demonstrated during infusion of saline. It is suggested that the marked increase in ICP during blood infusion into the subarachnoid space is caused by intracranial volume loading and the simultaneous increase in cerebrospinal fluid outflow resistance. It is concluded that the reported relationship between increased cerebrospinal fluid outflow resistance and increased ICP supports the hypothesis of a strong increase in ICP during subarachnoid hemorrhage in human subjects.
在猫身上研究了实验性蛛网膜下腔出血引起的颅内压（ICP）、ICP容积指数和脑脊液吸收阻力的早期变化。蛛网膜下腔出血后，颅内压略有升高，颅内空间的缓冲能力下降，流出阻力急剧上升。以恒定输注速率向小脑延髓池输注血液时，与输注生理盐水相比，可显示颅内压大幅升高，输注生理盐水仅导致颅内压略有升高。此外，在输注血液期间，颅内压水平未达到压力平台期，而输注生理盐水时则会出现平台期。提示向蛛网膜下腔输注血液期间颅内压的显著升高是由颅内容量负荷和脑脊液流出阻力同时增加所致。得出的结论是，所报道的脑脊液流出阻力增加与颅内压升高之间的关系支持了人类蛛网膜下腔出血期间颅内压大幅升高的假说。
