一类新型非 C2 对称配体在氧化和还原中性钯催化的 1,3-二酮不对称烯丙基烷基化反应中的应用。
A new class of non-C2-symmetric ligands for oxidative and redox-neutral palladium-catalyzed asymmetric allylic alkylations of 1,3-diketones.
机构信息
Department of Chemistry, Stanford University , Stanford, California 94305-5080, United States.
出版信息
J Am Chem Soc. 2015 Feb 25;137(7):2776-84. doi: 10.1021/jacs.5b00786. Epub 2015 Feb 16.
PMID:25629592
Abstract
We report the discovery, synthesis, and application of a new class of non-C2-symmetric phosphoramidite ligands derived from pyroglutamic acid for use in both oxidative and redox-neutral palladium-catalyzed asymmetric allylic alkylations of 1,3-diketones. The resulting chiral products are typically obtained in high yield with good to excellent levels of enantioselectivity.
摘要
我们报告了一类新型非 C2 对称的手性磷酰胺配体的发现、合成和应用，该配体来源于焦谷氨酸，可用于氧化和氧化还原中性钯催化的 1,3-二酮的不对称烯丙基烷基化反应。所得的手性产物通常以高产率和良好到优异的对映选择性获得。
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