University of Texas, Southwestern Medical Center, Children's Research Institute, Dallas, Texas 75390-8502, USA.
Nat Cell Biol. 2012 Feb 19;14(3):235-6. doi: 10.1038/ncb2449.
Tumour cells undergo oncogene-regulated metabolic reprogramming that maximizes survival and growth. However, little is known about metabolic interactions between tumour cells and their non-malignant neighbours in the stroma. Bone-marrow-derived stromal cells are now shown to provide cysteine, an essential nutrient that enables leukaemia cells to resist oxidative stress.
肿瘤细胞经历了癌基因调控的代谢重编程，以最大限度地提高生存和生长。然而，肿瘤细胞与其基质中非恶性相邻细胞之间的代谢相互作用知之甚少。现在已经表明，骨髓衍生的基质细胞提供半胱氨酸，这是一种必需的营养物质，使白血病细胞能够抵抗氧化应激。
