Alleva E, Calamandrei G
Behavioral Pathophysiology Section, Istituto Superiore di Sanità, Rome, Italy.
Neurotoxicology. 1990 Summer;11(2):293-303.
Protein molecules known as Growth Factors (GFs) appear to play an important regulatory role in a number of CNS functions. In particular Nerve Growth Factor (NGF), the best characterized among about 30 GF molecules, is endowed with specific activities on cholinergic and peptidergic CNS neurons. Indexes of neurobehavioral maturation are accelerated in the mouse by neonatal NGF exposure, while a similar treatment with EGF exerts both growth-promoting and growth-inhibiting effects on somatic and behavioral development. Scopolamine hyperactivity is enhanced around weaning by NGF pretreatment. Data are discussed along with (a) NGF prevention of cholinergic system damage and (b) the molecular mechanism of endogenously-triggered CNS repair processes.
被称为生长因子（GFs）的蛋白质分子似乎在许多中枢神经系统功能中发挥着重要的调节作用。特别是神经生长因子（NGF），在约30种生长因子分子中其特性研究得最为充分，它对胆碱能和肽能中枢神经系统神经元具有特定活性。新生小鼠暴露于NGF会加速神经行为成熟指标，而用表皮生长因子（EGF）进行类似处理对躯体和行为发育既有促进生长的作用，也有抑制生长的作用。在断奶前后，NGF预处理会增强东莨菪碱引起的多动。本文结合（a）NGF对胆碱能系统损伤的预防作用和（b）内源性触发的中枢神经系统修复过程的分子机制对数据进行了讨论。
