Alleva E, Calamandrei G
Behavioral Pathophysiology Section, Instituto Superiore di Sanità Rome, Italy.
Acta Neurobiol Exp (Wars). 1990;50(4-5):341-52.
A number of polypeptide growth factor molecules have been discovered and characterized in the recent years. Most of them appear to play important roles in the ontogeny of both vertebrates and invertebrates, and some growth factors are specifically involved in brain development of altricial mammals such as rats and mice. In particular, Nerve Growth Factor (NGF) seems to be involved in degenerative processes of the aged CNS and to control brain development, particularly cholinergic systems. Data concerning NGF effects on neurobehavioral development of neonatal mice are reported, and compared with the specific alterations caused by neonatal Epidermal Growth Factor (EGF) exposure on a number of physical and behavioral scores. While NGF mainly anticipated behavioral development, EGF exerted both growth-promoting and growth-inhibiting effects.
近年来，人们发现并鉴定了许多多肽生长因子分子。其中大多数似乎在脊椎动物和无脊椎动物的个体发育中发挥重要作用，一些生长因子特别参与了如大鼠和小鼠等晚成性哺乳动物的脑发育。特别是，神经生长因子（NGF）似乎参与了老年中枢神经系统的退行性过程，并控制脑发育，尤其是胆碱能系统。本文报道了有关NGF对新生小鼠神经行为发育影响的数据，并与新生小鼠暴露于表皮生长因子（EGF）所引起的一些身体和行为评分的特定改变进行了比较。虽然NGF主要促进行为发育，但EGF则发挥了促生长和抑生长的双重作用。
