各种肺部疾病中类似哮喘的峰值流速变异性。

Asthma-like peak flow variability in various lung diseases.

作者信息

Singh Virendra, Meena Pradeep, Sharma Bharat Bhushan

机构信息

Division of Allergy and Pulmonary Medicine, Department of Medicine, SMS Medical College Hospital, Jaipur, India.

出版信息

Lung India. 2012 Jan;29(1):15-8. doi: 10.4103/0970-2113.92352.

DOI:10.4103/0970-2113.92352

PMID:22345908

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3276026/

Abstract

BACKGROUND AND OBJECTIVES

Bronchodilator reversibility and diurnal peak flow variability are considered characteristic of asthma patients. Patients with chronic obstructive pulmonary disease (COPD) show poor reversibility. But reversibility and variability in other pulmonary diseases manifesting with airflow obstruction in not known. Therefore, we assessed reversibility and peak flow variability in patients with various lung diseases to recognize the pattern.

MATERIALS AND METHODS

Seventy consecutive patients with a diagnosis of lung diseases manifesting with airflow obstruction were recruited in the study. These included 23 patients with asthma, 11 patients with bronchiectasis, 16 patients with post-tubercular lung disease (PTLD), and 20 patients with COPD. Ten healthy matched control subjects were also selected to pair with asthmatic patients. Bronchodilator reversibility test was done initially and peak expiratory flow rate (PEFR) was measured for a duration of 1 week by patients themselves on a chart that was given to them. The mean amplitude percentage of these records were analyzed.

RESULTS

The mean values of peak flow variability were 14.73% ± 6.1% in asthmatic patients, 11.98% ± 7.5% in patients with bronchiectasis, and 10.54% ± 5.3% in PTLD. The difference in the mean values of peak flow variability between asthma and bronchiectasis, that is, 14.73 (6.1) vs 11.98 (7.5) was not statistically significant (P > 0.05). Forced expiratory volume one second (FEV(1)) reversibility values were 14.77% ± 26.93%, 11.24% ± 20.43%, 10.85% ± 13.02%, 16.83% ± 22.84%, and 5.47% ± 4.99% in asthma, COPD, PTLD, bronchiectasis, and healthy subjects, respectively.

CONCLUSION

Both reversibility and diurnal peak flow variability were higher in patients with various lung diseases compared with normal healthy subjects. Although these are characteristic of asthma, some cases of bronchiectasis and PTLD patients may also manifest asthma-like PEFR variability and reversibility.

摘要

背景与目的

支气管扩张剂可逆性和日最高呼气流量变异性被认为是哮喘患者的特征。慢性阻塞性肺疾病（COPD）患者表现出较差的可逆性。但其他表现为气流阻塞的肺部疾病的可逆性和变异性尚不清楚。因此，我们评估了各种肺部疾病患者的可逆性和最高呼气流量变异性，以识别其模式。

材料与方法

本研究纳入了70例连续诊断为表现为气流阻塞的肺部疾病患者。其中包括23例哮喘患者、11例支气管扩张症患者、16例肺结核后肺部疾病（PTLD）患者和20例COPD患者。还选择了10名健康匹配对照受试者与哮喘患者配对。最初进行支气管扩张剂可逆性测试，患者自行在提供的图表上记录1周的呼气峰值流速（PEFR）。分析这些记录的平均幅度百分比。

结果

哮喘患者的最高呼气流量变异性平均值为14.73%±6.1%，支气管扩张症患者为11.98%±7.5%，PTLD患者为10.54%±5.3%。哮喘和支气管扩张症之间最高呼气流量变异性平均值的差异，即14.73（6.1）对11.98（7.5），无统计学意义（P>0.05）。哮喘、COPD、PTLD、支气管扩张症和健康受试者的一秒用力呼气容积（FEV₁）可逆性值分别为14.77%±26.93%、11.24%±20.43%、10.85%±13.02%、16.83%±22.84%和5.47%±4.99%。