Agoston Denes V, Risling Mårten, Bellander Bo-Michael
Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences Bethesda, MD, USA.
Front Neurol. 2012 Feb 2;3:3. doi: 10.3389/fneur.2012.00003. eCollection 2012.
Traumatic brain injury (TBI) is one of the leading cause of death and long-term disability in virtually every country. Advances in neurointensive care have resulted in steadily decreasing morbidity, but the number of individuals with severe long-term disability have not changed significantly and the number of moderate disability has shown steady increase over the last 3 decades. Despite years of intensive preclinical research - and millions spent - there are virtually no drugs specifically developed to mitigate the consequences of TBI. Here we discuss some of the existing gaps between clinical and experimental TBI studies that may have contributed to the current status. We do this hoping that clinical, basic, and translational scientists will design and coordinate studies in order to achieve maximum benefits for TBI patients. In conclusion, we suggest to: (1) Develop consensus-based guidelines for experimental TBI research, similar to "best practices" in the clinic; (2) Generate a consensus-based template for clinical data collection and deposition as well as for experimental TBI data collection and deposition; (3) Use a systems biology approach and create a database for integrating existing data from basic and clinical research.
创伤性脑损伤（TBI）几乎是每个国家死亡和长期残疾的主要原因之一。神经重症监护的进展已使发病率稳步下降，但严重长期残疾的人数并未显著改变，中度残疾的人数在过去30年中呈稳步上升趋势。尽管进行了多年的深入临床前研究且花费了数百万美元，但实际上并没有专门开发用于减轻TBI后果的药物。在此，我们讨论临床和实验性TBI研究之间现有的一些差距，这些差距可能导致了当前的状况。我们这样做是希望临床、基础和转化科学家能够设计并协调研究，以便为TBI患者带来最大益处。总之，我们建议：（1）制定基于共识的实验性TBI研究指南，类似于临床中的“最佳实践”；（2）生成基于共识的临床数据收集与存储以及实验性TBI数据收集与存储的模板；（3）采用系统生物学方法并创建一个数据库，用于整合基础研究和临床研究的现有数据。
