过氧化物酶体增殖物激活受体α基因内含子7多态性与冠状动脉疾病的关联：一项横断面研究。
Association of PPARα Intron 7 Polymorphism with Coronary Artery Disease: A Cross-Sectional Study.
作者信息
Purushothaman Sreeja, Ajitkumar V K, Renuka Nair R
机构信息
Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram 695 011, India.
出版信息
ISRN Cardiol. 2011;2011:816025. doi: 10.5402/2011/816025. Epub 2011 Apr 7.
Abstract
The allelic variants of peroxisome proliferator-activated receptor alpha (PPARα) can influence the risk of coronary artery disease (CAD) by virtue of its effect on lipid metabolism. However, the role of PPARα intronic polymorphism with CAD has received little attention. The association of allelic variants G/C at intron 7 of the PPAR-alpha gene with CAD was examined in a hospital-based Indian population. PPAR genotyping was performed in 110 male patients with CAD and 120 age and ethnically matched healthy males by PCR amplification of the gene followed by restriction digestion. Presence of C allele showed a positive association with CAD (OR = 2.9; 95% CI [1.65-4.145]; P = .009) and also with dyslipidaemia (OR = 2.95, 95% CI (1.5-4.39); P < .05). Impaired lipid metabolism in carriers of the PPARα Intron 7C allele is possibly responsible for the predilection to CAD.
摘要
过氧化物酶体增殖物激活受体α（PPARα）的等位基因变体可通过影响脂质代谢来影响冠状动脉疾病（CAD）的风险。然而，PPARα内含子多态性在CAD中的作用很少受到关注。在一个以医院为基础的印度人群中，研究了PPAR-α基因第7内含子等位基因变体G/C与CAD的关联。通过对该基因进行PCR扩增，然后进行限制性消化，对110名男性CAD患者和120名年龄和种族匹配的健康男性进行了PPAR基因分型。C等位基因的存在与CAD呈正相关（OR = 2.9；95% CI [1.65 - 4.145]；P = .009），也与血脂异常呈正相关（OR = 2.95，95% CI（1.5 - 4.39）；P < .05）。PPARα第7内含子C等位基因携带者的脂质代谢受损可能是其易患CAD的原因。
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