Sachdev M S, Mehta M R, Dada V K, Jain A K, Garg S P, Gupta S K
Dr Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
Ophthalmic Surg. 1990 Aug;21(8):557-9.
In a prospective, randomized, double-blind trial, we evaluated the relative efficacy of indomethacin and flurbiprofen when used as adjuvants to routinely used mydriatics for maintenance of pupillary dilatation in patients with heavily pigmented iris undergoing extracapsular cataract extraction. The drugs were administered orally as well as topically according to a fixed regimen. The pupillary diameters, measured with calipers at various surgical steps, were significantly larger at every step in the study groups in which either of the adjuvants had been used than they were in the control group (P less than .001). Flurbiprofen tended to help maintain a larger pupillary diameter in the later stages of surgery than indomethacin, but this difference was not statistically significant. We conclude that it is important to use prostaglandin synthetase inhibitors as adjuvants to routine mydriatics, and that flurbiprofen may be somewhat more effective than indomethacin in this capacity.
在一项前瞻性、随机、双盲试验中，我们评估了吲哚美辛和氟比洛芬作为辅助药物与常规散瞳剂联合使用时，对患有色素沉着严重的虹膜患者行白内障囊外摘除术时维持瞳孔散大的相对疗效。按照固定方案经口服和局部给予这些药物。在各个手术步骤中，使用卡尺测量瞳孔直径，结果发现，在使用任何一种辅助药物的研究组中，各步骤的瞳孔直径均显著大于对照组（P<0.001）。在手术后期，氟比洛芬倾向于比吲哚美辛更有助于维持较大的瞳孔直径，但这种差异无统计学意义。我们得出结论，使用前列腺素合成酶抑制剂作为常规散瞳剂的辅助药物很重要，并且在此方面氟比洛芬可能比吲哚美辛稍有效。
