Jackson H, Patel C K, Westcott M, Thompson G M, Mathalone B M
Department of Ophthalmology, St George's Hospital, London, UK.
Eye (Lond). 1994;8 ( Pt 3):329-31. doi: 10.1038/eye.1994.67.
Pre-operative topical non-steroidal anti-inflammatory drugs (NSAIDs) are known to be effective in maintaining pupillary dilation during cataract surgery. However, previous studies have suggested that pre-treatment with these agents interferes with the miosis produced by intraoperative acetylcholine injection. This study was designed to determine whether the pupillary response to acetylcholine injection is reduced following pre-operative topical flurbiprofen 0.03%. Pupil diameters were measured with a millimetre rule, and the measurements verified using computerised image analysis of digitised video images. Eyes treated with flurbiprofen were compared with controls. There was no significant difference in pupillary diameter before corneal incision, but following aspiration of soft lens matter and insertion of intraocular lens the pupil was significantly larger in the flurbiprofen group (p = 0.002). At 1.0, 2.5 and 5.0 minutes following injection of acetylcholine no significant difference in the degree of miosis was detected. This study confirms that topical flurbiprofen maintains dilation during cataract surgery, and does not find any evidence to suggest that intra-operative response to acetylcholine is reduced.
术前局部使用非甾体抗炎药（NSAIDs）已知在白内障手术期间维持瞳孔散大方面有效。然而，先前的研究表明，用这些药物进行预处理会干扰术中注射乙酰胆碱所产生的瞳孔缩小。本研究旨在确定术前局部使用0.03%氟比洛芬后，对乙酰胆碱注射的瞳孔反应是否降低。用毫米尺测量瞳孔直径，并使用数字化视频图像的计算机图像分析来验证测量结果。将使用氟比洛芬治疗的眼睛与对照组进行比较。角膜切开术前瞳孔直径无显著差异，但在吸出软性晶状体物质并植入人工晶状体后，氟比洛芬组的瞳孔明显更大（p = 0.002）。注射乙酰胆碱后1.0、2.5和5.0分钟，未检测到瞳孔缩小程度的显著差异。本研究证实，局部使用氟比洛芬在白内障手术期间维持瞳孔散大，并且没有发现任何证据表明术中对乙酰胆碱的反应降低。
