Sachdev M S, Singh K, Talwar D, Gupta S K, Dada V K
Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi.
Ophthalmic Surg. 1994 Feb;25(2):92-4.
A double-blind, prospective, randomized clinical study was undertaken to evaluate the relative efficacy of flurbiprofen 0.03% and diclofenac 0.1% eye drops, in combination with routinely used mydriatics, in maintaining pupillary dilatation during extracapsular cataract surgery with intraocular lens implantation. The effectiveness of administering systemic flurbiprofen along with the topical drugs in enhancing maintenance of pupillary dilatation also was assessed. Pupillary diameter, as measured at various surgical stages, was significantly greater in the patients receiving diclofenac or flurbiprofen eye drops as compared with those in a control group who did not (P < .001). While the maintenance of pupillary dilatation was consistently better with diclofenac than with flurbiprofen, the difference was not statistically significant. Furthermore, though maintenance of pupillary dilatation was better in cases in which systemic flurbiprofen was added to the preoperative drug regime, again, the difference was not significant.
开展了一项双盲、前瞻性、随机临床研究，以评估0.03%氟比洛芬滴眼液和0.1%双氯芬酸滴眼液与常规使用的散瞳剂联合应用，在白内障囊外摘除联合人工晶状体植入手术中维持瞳孔散大的相对疗效。还评估了全身应用氟比洛芬与局部用药联合使用在增强瞳孔散大维持效果方面的有效性。在各个手术阶段测量的瞳孔直径，接受双氯芬酸或氟比洛芬滴眼液治疗的患者明显大于未接受治疗的对照组患者（P <.001）。虽然双氯芬酸维持瞳孔散大的效果始终优于氟比洛芬，但差异无统计学意义。此外，虽然术前用药方案中添加全身氟比洛芬的情况下瞳孔散大维持得更好，但同样差异不显著。
