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2
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Insulin-like growth factor-1 receptor and ErbB kinase inhibitor combinations block proliferation and induce apoptosis through cyclin D1 reduction and Bax activation.胰岛素样生长因子-1受体与表皮生长因子受体激酶抑制剂联合使用可通过降低细胞周期蛋白D1和激活Bax来阻止细胞增殖并诱导细胞凋亡。
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本文引用的文献

1
Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: optimization of the aniline.新型咪唑并[1,2-a]吡啶类 IGF-1 受体酪氨酸激酶抑制剂的研究：苯胺基的优化。
Bioorg Med Chem Lett. 2011 Aug 15;21(16):4702-4. doi: 10.1016/j.bmcl.2011.06.090. Epub 2011 Jun 25.
2
BCL-2, in combination with MVP and IGF-1R expression, improves prediction of clinical outcome in complete response cervical carcinoma patients treated by radiochemotherapy.BCL-2 联合 MVP 和 IGF-1R 表达可改善放化疗完全缓解宫颈癌患者临床结局的预测。
Gynecol Oncol. 2011 Sep;122(3):585-9. doi: 10.1016/j.ygyno.2011.05.037. Epub 2011 Jun 25.
3
IGF-1R expression predicts clinical outcome in patients with locally advanced oral squamous cell carcinoma.IGF-1R 表达可预测局部晚期口腔鳞状细胞癌患者的临床结局。
Oral Oncol. 2011 Jul;47(7):615-9. doi: 10.1016/j.oraloncology.2011.05.005. Epub 2011 Jun 2.
4
Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors.发现 2,4-双芳基氨基-1,3-嘧啶作为胰岛素样生长因子-1 受体（IGF-1R）抑制剂。
Bioorg Med Chem Lett. 2011 Apr 15;21(8):2394-9. doi: 10.1016/j.bmcl.2011.02.075. Epub 2011 Feb 23.
5
Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways.DNA 双链断裂的诱导和修复：非同源末端连接途径的不断增加。
Mutat Res. 2011 Jun 3;711(1-2):61-72. doi: 10.1016/j.mrfmmm.2011.02.005. Epub 2011 Feb 15.
6
Insulin-like growth factor-I receptor inhibition by specific tyrosine kinase inhibitor NVP-AEW541 in endometrioid and serous papillary endometrial cancer cell lines.特定酪氨酸激酶抑制剂 NVP-AEW541 对子宫内膜样和浆液性乳头状子宫内膜癌细胞系中胰岛素样生长因子-I 受体的抑制作用。
Gynecol Oncol. 2011 May 1;121(2):383-9. doi: 10.1016/j.ygyno.2011.01.008. Epub 2011 Feb 3.
7
Potent and selective cyclohexyl-derived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy.强效且选择性的环己基衍生咪唑并吡嗪胰岛素样生长因子 1 受体抑制剂，具有体内疗效。
Bioorg Med Chem Lett. 2011 Feb 15;21(4):1176-80. doi: 10.1016/j.bmcl.2010.12.094. Epub 2010 Dec 23.
8
The insulin-like growth factor-1 receptor kinase inhibitor, NVP-ADW742, suppresses survival and resistance to chemotherapy in acute myeloid leukemia cells.胰岛素样生长因子-1 受体激酶抑制剂 NVP-ADW742 抑制急性髓系白血病细胞的存活和对化疗的耐药性。
Oncol Res. 2010;19(1):35-43. doi: 10.3727/096504010x12828372551821.
9
Combination of anti-IGF-1R antibody A12 and ionizing radiation in upper respiratory tract cancers.抗 IGF-1R 抗体 A12 与电离辐射联合治疗上呼吸道癌。
Int J Radiat Oncol Biol Phys. 2011 Mar 15;79(4):1179-87. doi: 10.1016/j.ijrobp.2010.10.003. Epub 2010 Dec 2.
10
Cancer treatment strategies targeting sphingolipid metabolism.靶向鞘脂代谢的癌症治疗策略。
Adv Exp Med Biol. 2010;688:185-205. doi: 10.1007/978-1-4419-6741-1_13.

IGF-1 受体在辐射反应中的作用。

Role of IGF-1 receptor in radiation response.

机构信息

Instituto Canario de Investigación del Cáncer, Canary Islands, Spain.

出版信息

Transl Oncol. 2012 Feb;5(1):1-9. doi: 10.1593/tlo.11265. Epub 2012 Feb 1.

DOI:10.1593/tlo.11265
PMID:22348170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3281411/
Abstract

Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositide 3-kinase pathways. In addition to their traditional roles, IGF-1R activation has been associated with increased radioresistance both in vitro and in vivo, although the molecular mechanisms behind this process are still unclear. Recently, IGF-1R has been associated to new partners as major vault proteins, BCL-2, BAX, or Ku70/80, related to radiochemotherapy resistance, regulation of apoptosis, and nonhomologous end-joining DNA repair. Here, we review these novel associations of IGF-1R trying to explain the resistance to radiotherapy mediated by IGF-1R. Finally, we revised the role of new therapies leading to block the receptor to enhance the efficacy of radiation.

摘要

胰岛素样生长因子 1 受体（IGF-1R）是一种跨膜受体酪氨酸激酶，参与癌症的发生和发展，其激活强烈促进细胞生长和存活。IGF-1R 通过激活丝裂原活化蛋白激酶和磷酸肌醇 3-激酶途径发挥其主要作用。除了它们的传统作用外，IGF-1R 的激活与体外和体内的放射抗性增加有关，尽管这一过程背后的分子机制尚不清楚。最近，IGF-1R 与主要穹窿蛋白、BCL-2、BAX 或 Ku70/80 等新的伙伴蛋白相关联，这些蛋白与放化疗耐药、细胞凋亡调节和非同源末端连接 DNA 修复有关。在这里，我们综述了 IGF-1R 的这些新的关联，试图解释 IGF-1R 介导的放射治疗抵抗。最后，我们回顾了导致阻断受体以增强辐射疗效的新疗法的作用。