Finnish Red Cross Blood Service, Helsinki, Finland.
Vox Sang. 2012 Aug;103(2):93-8. doi: 10.1111/j.1423-0410.2012.01591.x. Epub 2012 Feb 20.
Bacterial infection through contaminated blood is currently the greatest infection risk in relation to a transfusion. Deferral of prospective blood donors with a skin disorder is a common practise, because bacteria usually originate from the donor's skin. The effectiveness of current deferral guidelines to prevent the bacterial contamination of blood has not been assessed.
We recruited 55 blood donors with a skin disorder that prevented donation, and matched three controls for each case. The donors filled out a questionnaire and one bacterial culture sample was taken from venepuncture forearm skin.
The median total number of colony forming skin bacteria was significantly higher in the cases (224 CFUs per sample) than controls (105 CFU per sample). Staphylococcus aureus was significantly more often present on the skin in cases (49%) as compared to controls (7%). Regarding other bacterial genera, no difference between cases and controls was found.
This study shows that our current guidelines for deferral of blood donors with skin disorders effectively identifies individuals with a high number of bacteria on their skin, as well as S. aureus carriers. However, deferral due to skin disorders had only a minor impact on blood product contamination when compared to other actions.
目前，通过污染血液的细菌感染是与输血相关的最大感染风险。有皮肤疾病的潜在献血者被延期献血是常见做法，因为细菌通常来源于供体的皮肤。尚未评估当前延期献血指南预防血液细菌污染的有效性。
我们招募了 55 名因皮肤疾病而无法献血的献血者，并为每位病例匹配了 3 名对照。献血者填写了一份问卷，并且从肘静脉穿刺前臂皮肤采集了一个细菌培养样本。
病例组（每个样本 224 CFU）的皮肤细菌总菌落形成数明显高于对照组（每个样本 105 CFU）。与对照组（7%）相比，病例组（49%）皮肤中金黄色葡萄球菌的存在明显更为常见。对于其他细菌属，病例组与对照组之间未发现差异。
本研究表明，我们目前针对有皮肤疾病的献血者延期献血的指南有效地识别出皮肤细菌数量较高的个体，以及金黄色葡萄球菌携带者。然而，与其他措施相比，由于皮肤疾病而延期献血对血液制品污染的影响较小。
