Cognitive Neuroscience Laboratory, Department of Psychology, Babeş-Bolyai University, Cluj-Napoca, Romania.
Genes Brain Behav. 2012 Jun;11(4):398-403. doi: 10.1111/j.1601-183X.2012.00774.x. Epub 2012 Mar 9.
This study investigated whether somatic markers mediate the effect of serotonin transporter genotype on Iowa Gambling Task (IGT) performance. Participants (N = 135) were genotyped for the insertion/deletion and single-nucleotide (rs25531) polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR). The results of mediation analyses indicated that skin conductance responses that anticipated IGT card selections partially (i.e. 42% of the total effect) mediated the effect of genotype on IGT performance. In comparison with high-functioning 5-HTTLPR genotypes, the low-functioning genotypes were associated with higher total IGT scores. This suggests that the higher synaptic availability of serotonin, associated with the low-functioning 5-HTTLPR genotypes, may confer differential susceptibility to decision making under risk, and that almost half of this effect is explained by facilitated somatic markers during IGT.
本研究旨在探讨躯体标记是否在 5-羟色胺转运体基因（5-HTTLPR）启动子区域的插入/缺失和单核苷酸（rs25531）多态性对爱荷华赌博任务（IGT）表现的影响中起中介作用。参与者（N=135）接受了 5-羟色胺转运体基因 5-HTTLPR 的插入/缺失和单核苷酸（rs25531）多态性的基因分型。中介分析的结果表明，预期 IGT 卡选择的皮肤电反应部分（即基因型对 IGT 表现影响的 42%）介导了基因型对 IGT 表现的影响。与高功能 5-HTTLPR 基因型相比，低功能基因型与更高的总 IGT 分数相关。这表明，与低功能 5-HTTLPR 基因型相关的较高的血清素突触可利用性可能使风险决策下的易感性产生差异，而这一效应的近一半可以通过 IGT 期间促进躯体标记来解释。
