Zitman F G, Linssen A C G, Edelbroek P M, Stijnen T
Department of Psychiatry, Catholic University Nijmegen, 6500 HB NijmegenThe Netherlands Department of Psychiatry, University Hospital, 2300 RC LeidenThe Netherlands Toxicology Laboratory, University Hospital, 2300 RC LeidenThe Netherlands Department of Medical Statistics, University of Leiden, 2300 RC LeidenThe Netherlands.
Pain. 1990 Jul;42(1):35-42. doi: 10.1016/0304-3959(90)91089-2.
In the double-blind placebo-controlled study presented here, the effects were investigated of a low dose of amitriptyline (75 mg) in patients with chronic pain of various origins. The active drug was superior to placebo in reducing pain intensity. The reduction was small. In the second treatment week, the amitriptyline treated patients slept longer. No differences between active drug and placebo were found with respect to daily activities or use of analgesics. Based on our data and those of other studies, it is concluded that amitriptyline (and other antidepressants) in low doses does have a positive effect on the intensity and some other aspects of chronic pain, but that the effect is modest. It must be kept in mind that chronic pain is a very treatment-resistant condition. Therefore, even modest positive effects may be worthwhile.
在本文所呈现的双盲安慰剂对照研究中，对低剂量阿米替林（75毫克）用于各种病因所致慢性疼痛患者的效果进行了调查。活性药物在减轻疼痛强度方面优于安慰剂。疼痛强度的降低幅度较小。在第二个治疗周，服用阿米替林的患者睡眠时间更长。在日常活动或使用镇痛药方面，未发现活性药物与安慰剂之间存在差异。基于我们的数据以及其他研究的数据，得出的结论是，低剂量的阿米替林（以及其他抗抑郁药）确实对慢性疼痛的强度和其他一些方面具有积极作用，但这种作用较为适度。必须牢记，慢性疼痛是一种极难治疗的病症。因此，即使是适度的积极作用也可能是值得的。
