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肿瘤学领域的代谢组学:近期研究综述。

Metabolomics in the fields of oncology: a review of recent research.

机构信息

Department of Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai 200072, PR China.

出版信息

Mol Biol Rep. 2012 Jul;39(7):7505-11. doi: 10.1007/s11033-012-1584-1. Epub 2012 Feb 16.

DOI:10.1007/s11033-012-1584-1
PMID:22350159
Abstract

The study of all endogenously produced metabolites, known as metabolomics, is the youngest of the "omics" sciences. It is becoming increasingly clear that, of all of the "omics" techniques, metabolomic approaches will become increasingly useful in disease diagnosis and have potential power to improve our understanding of the underlying mechanisms of cancer. The primary aim of the review is to discuss the relationship between metabolomics and tumors are elucidated in detail. Then the review is also to introduce the technologies of metabolomics, especially emphasizing the application of metabolomics in the fields of oncology.

摘要

对所有内源性代谢产物的研究,被称为代谢组学,是“组学”科学中最年轻的一个。越来越明显的是,在所有“组学”技术中,代谢组学方法在疾病诊断方面将变得越来越有用,并有可能增进我们对癌症潜在机制的理解。本综述的主要目的是详细讨论代谢组学与肿瘤之间的关系。然后,该综述还介绍了代谢组学技术,特别是强调了代谢组学在肿瘤学领域的应用。

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本文引用的文献

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Global metabolic profiling procedures for urine using UPLC-MS.采用 UPLC-MS 进行尿液的全局代谢物分析程序。
Nat Protoc. 2010 Jun;5(6):1005-18. doi: 10.1038/nprot.2010.50.
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Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection.结直肠癌患者血清中羟化、多不饱和超长链脂肪酸水平降低:对早期筛查和检测的意义。
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Evaluation of full-resolution J-resolved 1H NMR projections of biofluids for metabonomics information retrieval and biomarker identification.
Tissue and serum lipidome shows altered lipid composition with diagnostic potential in mycosis fungoides.
组织和血清脂质组显示蕈样肉芽肿中脂质成分改变,具有诊断潜力。
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A 1H-NMR Based Study on Hemolymph Metabolomics in Eri Silkworm after Oral Administration of 1-Deoxynojirimycin.基于1H-NMR的1-脱氧野尻霉素口服给药后蓖麻蚕血淋巴代谢组学研究
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A gas chromatography-mass spectrometry based study on urine metabolomics in rats chronically poisoned with hydrogen sulfide.一项基于气相色谱-质谱联用技术的大鼠慢性硫化氢中毒尿液代谢组学研究。
Biomed Res Int. 2015;2015:295241. doi: 10.1155/2015/295241. Epub 2015 Apr 14.
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Application of metabolomics in drug resistant breast cancer research.代谢组学在耐药性乳腺癌研究中的应用。
Metabolites. 2015 Feb 16;5(1):100-18. doi: 10.3390/metabo5010100.
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Computational tools for the secondary analysis of metabolomics experiments.代谢组学实验二次分析的计算工具。
Comput Struct Biotechnol J. 2013 Feb 6;4:e201301003. doi: 10.5936/csbj.201301003. eCollection 2013.
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Altered tissue metabolites correlate with microbial dysbiosis in colorectal adenomas.结直肠腺瘤中组织代谢物的改变与微生物群落失调相关。
J Proteome Res. 2014 Apr 4;13(4):1921-9. doi: 10.1021/pr4009783. Epub 2014 Mar 21.
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Metabolomics. 2014;10(1):141-151. doi: 10.1007/s11306-013-0565-2. Epub 2013 Jul 20.
10
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Int J Mol Sci. 2013 Apr 24;14(5):8899-911. doi: 10.3390/ijms14058899.
评估用于代谢组学信息检索和生物标志物识别的生物流体全分辨率 J 分辨 1H NMR 投影。
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A new NMR-based metabolomics approach for the diagnosis of biliary tract cancer.一种基于 NMR 的代谢组学新方法用于胆管癌的诊断。
J Hepatol. 2010 Feb;52(2):228-33. doi: 10.1016/j.jhep.2009.11.002. Epub 2009 Nov 27.
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Multivariate modeling and prediction of breast cancer prognostic factors using MR metabolomics.多变量建模和预测使用磁共振代谢组学的乳腺癌预后因素。
J Proteome Res. 2010 Feb 5;9(2):972-9. doi: 10.1021/pr9008783.
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Metabonomics study of liver cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations.基于超高效液相色谱-质谱联用技术(采用亲水作用色谱和反相液相色谱分离)的肝癌代谢组学研究
Anal Chim Acta. 2009 Sep 14;650(1):3-9. doi: 10.1016/j.aca.2009.03.039. Epub 2009 Apr 1.
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Metabonomic studies of human hepatocellular carcinoma using high-resolution magic-angle spinning 1H NMR spectroscopy in conjunction with multivariate data analysis.使用高分辨率魔角旋转1H核磁共振波谱结合多变量数据分析对人类肝细胞癌进行代谢组学研究。
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