Communication Disorders Program and Neuroscience Institute, Georgia State University, Atlanta, GA, USA.
J Clin Exp Neuropsychol. 2012;34(5):489-96. doi: 10.1080/13803395.2012.658356. Epub 2012 Feb 22.
The current study explored the complicated interplay between aphasia and the stress biomarker, cortisol, in left-hemisphere (LH) and right-hemisphere (RH) stroke patients. Nineteen LH patients and 12 RH patients began the study between one to six months post stroke and were followed for three months. During this time, language skills were assessed monthly while afternoon salivary cortisol samples were collected biweekly. The LH and RH groups showed improvements in language test scores over the course of three months; however, only naming skills in the RH group appeared to be associated with afternoon salivary cortisol levels. Furthermore, contradicting previous reports regarding laterality and cortisol regulation in humans, the current study found that both LH patients and RH patients exhibited similar afternoon salivary cortisol levels across all time points.
本研究探讨了失语症与应激生物标志物皮质醇之间在左半球（LH）和右半球（RH）中风患者中的复杂相互作用。19 名 LH 患者和 12 名 RH 患者在中风后 1 至 6 个月开始研究，并随访了 3 个月。在此期间，每月评估语言技能，每两周采集一次下午唾液皮质醇样本。LH 和 RH 组在三个月的时间里语言测试分数都有所提高；然而，只有 RH 组的命名技能似乎与下午唾液皮质醇水平有关。此外，与先前关于人类侧化和皮质醇调节的报告相矛盾的是，本研究发现，LH 患者和 RH 患者在所有时间点的下午唾液皮质醇水平相似。
