Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
Psychiatry Clin Neurosci. 2012 Mar;66(2):87-96. doi: 10.1111/j.1440-1819.2011.02300.x.
While volumetric and metabolic imaging on post-traumatic stress disorder (PTSD) patients has been intensively performed, few studies using electroencephalograms (EEG) have been done as yet. The aim of the present study was to investigate abnormalities in functional connectivity of cortical networks in PTSD.
Non-linear interdependence (NI), a measure of bidirectional, non-linear information transmission between two time series, was used. Resting EEG were recorded for 18 PTSD patients and 18 sex-matched healthy subjects on 16 channels with their eyes closed.
The NI patterns in PTSD patients were hemisphere asymmetric: an increase in NI in the fronto-parieto-temporal regions of the left hemisphere (F7, F3, T3, C3, T5 and P3) and a decrease in the fronto-parieto-occipital regions of the right hemisphere (F4, C4, P4 and O2). The non-linearity of NI in EEG, estimated from the surrogate data method, exhibited an increase in the PTSD patients as compared with that of healthy subjects, particularly in the left hemispheric cortex.
Abnormal functional connectivity in PTSD can be assessed using NI, a measure of multi-channel EEG.
尽管针对创伤后应激障碍（PTSD）患者的容积和代谢成像已经得到了广泛的研究，但使用脑电图（EEG）的研究却很少。本研究旨在探讨 PTSD 患者皮质网络功能连接异常。
使用非线性互相关（NI），这是一种衡量两个时间序列之间双向非线性信息传递的方法。18 名 PTSD 患者和 18 名性别匹配的健康对照者在闭眼的情况下，通过 16 个通道记录了静息 EEG。
PTSD 患者的 NI 模式呈半球不对称：左半球额顶颞区（F7、F3、T3、C3、T5 和 P3）的 NI 增加，而右半球额顶枕区（F4、C4、P4 和 O2）的 NI 减少。从替代数据方法估计的 EEG 的 NI 非线性，与健康对照组相比，PTSD 患者的增加更为明显，尤其是在左半球皮质。
使用 NI 可以评估 PTSD 中的异常功能连接，NI 是一种多通道 EEG 的测量方法。
