Lee Seung-Hwan, Yoon Sunkyung, Kim Jeong-In, Jin Seung-Hyun, Chung Chun Kee
Department of Psychiatry, Inje University, Ilsan-Paik Hospital, 2240 Daehwa-dong, Ilsanseo-gu, Goyang, Republic of Korea; Clinical Emotion and Cognition Research Laboratory, 2240 Daehwa-dong, Ilsanseo-gu, Goyang, Republic of Korea.
Clinical Emotion and Cognition Research Laboratory, 2240 Daehwa-dong, Ilsanseo-gu, Goyang, Republic of Korea; Department of Psychology, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul, Republic of Korea.
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:51-7. doi: 10.1016/j.pnpbp.2014.01.008. Epub 2014 Jan 19.
Post-traumatic stress disorder (PTSD) is thought to be a brain network disorder. This study aimed to examine the resting-state functional connectivity (FC) in patients with PTSD.
Thirty-three PTSD patients and 30 age- and gender-matched healthy controls were recruited. Symptom severity of the PTSD patients was assessed, and 62-channel EEG was measured. EEGs were recorded during the resting state, with the eyes closed. Three nodal network measures to assess nodal centrality [nodal degree (Dnodal; connection strength), nodal efficiency (Enodal; communication efficiency), and betweenness centrality (BC; connection centrality)] were calculated in the delta, theta, alpha, beta, and gamma bands.
Dnodal and Enodal of the beta and gamma bands were decreased in PTSD patients compared to healthy controls. These decreased nodal centrality values were observed primarily at the frontocentral electrodes. In addition, Dnodal of the beta and gamma bands was significantly correlated with depressive symptoms and increased arousal symptoms, respectively. Enodal of the beta and gamma bands was significantly correlated with re-experience, increased arousal, and the severity and frequency of general PTSD symptoms.
Compared to controls, patients with PTSD were found to have decreased resting-state FC, and these FC measures were significantly correlated with PTSD symptom severity. Our results suggest that resting-state FC could be a useful biomarker for PTSD.
创伤后应激障碍（PTSD）被认为是一种脑网络障碍。本研究旨在检查PTSD患者的静息态功能连接（FC）。
招募了33名PTSD患者和30名年龄及性别匹配的健康对照者。评估PTSD患者的症状严重程度，并测量62通道脑电图。在静息状态下闭眼记录脑电图。计算了δ、θ、α、β和γ频段中用于评估节点中心性的三种节点网络测量指标[节点度（Dnodal；连接强度）、节点效率（Enodal；通信效率）和介数中心性（BC；连接中心性）]。
与健康对照者相比，PTSD患者β和γ频段的Dnodal和Enodal降低。这些降低的节点中心性值主要在额中央电极处观察到。此外，β和γ频段的Dnodal分别与抑郁症状和觉醒症状增加显著相关。β和γ频段的Enodal与重新体验、觉醒增加以及PTSD总体症状的严重程度和频率显著相关。
与对照组相比，发现PTSD患者的静息态FC降低，并且这些FC测量指标与PTSD症状严重程度显著相关。我们的结果表明，静息态FC可能是PTSD的一种有用生物标志物。
