Departamento de Fisiología, Facultad de Medicina, Universidad de Alcalá, Madrid, Spain.
J Ethnopharmacol. 2012 Apr 10;140(3):545-9. doi: 10.1016/j.jep.2012.02.008. Epub 2012 Feb 14.
ETHNO-PHARMACOLOGICAL RELEVANCE: The scientific proof and clinical validation of Chinese herbal medicine (CHM) require a rigorous approach that includes chemical standardization, biological assays, animal studies and clinical trials.
To assess the experimental design of animal studies on the activity of CHM by selection and scrutinizing of a series of papers in some major disease areas.
We have analyzed the English publications reported in MEDLINE (ISI web of knowledge).
Our data showed that (i) research of CHM during the last 10 years had been highly intensified and become more accessible worldwide through increased publications in English, although still most authors had Chinese names; (ii) English journals publishing animal research of CHM were comparable to those publishing animal studies of non-Chinese phytotherapy in terms of impact factor; and (iii) published data on authentication and quality control of CHM, as well as research design of animal studies were far from sufficient to meet the criteria needed to support their reproducibility and reliability.
The recent decade witnessed an increase in CHM research activities and CHM English publications. Based on common problems identified in publications on CHM animal studies, we have proposed a checklist that could help in preliminary selection of publications lacking the most common problems and thus would be useful for a quick search of reproducible CHM regimens that are likely to be effective in a given context. The second application of this checklist is to help avoid the most common problems when designing experiments.
民族药理学相关性：中药（CHM）的科学证明和临床验证需要一种严格的方法，包括化学标准化、生物测定、动物研究和临床试验。
通过选择和仔细审查一些主要疾病领域的一系列论文，评估 CHM 活性的动物研究的实验设计。
我们分析了 MEDLINE（ISI web of knowledge）中的英文出版物。
我们的数据表明：（i）过去 10 年来，CHM 的研究得到了高度加强，并通过增加英文出版物在全球范围内变得更加容易获得，尽管大多数作者仍有中文名字；（ii）出版 CHM 动物研究的英文期刊在影响因子方面与出版非中药植物疗法动物研究的期刊相当；（iii）发表的关于 CHM 的鉴定和质量控制以及动物研究设计的数据远远不足以满足支持其可重复性和可靠性所需的标准。
最近十年见证了 CHM 研究活动和 CHM 英文出版物的增加。基于在 CHM 动物研究出版物中发现的常见问题，我们提出了一个清单，可帮助初步选择缺乏最常见问题的出版物，从而有助于快速搜索在给定情况下可能有效的可重复使用的 CHM 方案。该清单的第二个应用是在设计实验时避免最常见的问题。
