Suh Seungchul, Nah Jong Chun, Uhm Min Sik, Jung Youn Mu, Kim Nayoung, Lee Dong Ho, Jung Hyun Chae, Song In Sung
Department of Internal Medicine, Seoul National University, Gyeonggi-do, Korea.
Hepatogastroenterology. 2012 Mar-Apr;59(114):646-8. doi: 10.5754/hge10277.
BACKGROUND/AIMS: There have been few reports comparing pre and postoperative prevalence of Helicobacter pylori infection and gastritis in patients with gastric cancer surgery.
Seventy patients with primary gastric cancer were identified to be infected with Helicobacter pylori preoperatively and tested for Helicobacter pylori infection after subtotal gastrectomy. We analyzed changes in Helicobacter pylori infectivity and histological features of gastric mucosa.
The overall spontaneous regression rate of Helicobacter pylori infection was 38.6% (27/70). The mean time between surgery and follow-up tests was 1.02±0.5 years. The activity and chronic inflammation scores were significantly decreased in regression group. In non-regression group, there was no significant difference in activity scores, but the chronic inflammation score was significantly increased. There were no significant changes in atrophic gastritis and intestinal metaplasia scores in either group. The grade of Helicobacter pylori infection was significantly decreased in non-regression group.
The spontaneous regression rate of Helicobacter pylori infection after subtotal gastrectomy was 38.6% (27/70), it occurred in larger scale of patients and it occurred earlier (1.02±0.5 years) than in previous studies. We suggest that further prospective study on spontaneous regression rate of Helicobacter pylori infection after subtotal gastrectomy and its mechanism is needed in the future.
背景/目的：关于胃癌手术患者术前和术后幽门螺杆菌感染及胃炎患病率比较的报道较少。
70例原发性胃癌患者术前被确定感染幽门螺杆菌，在胃大部切除术后检测幽门螺杆菌感染情况。我们分析了幽门螺杆菌感染性及胃黏膜组织学特征的变化。
幽门螺杆菌感染的总体自发清除率为38.6%（27/70）。手术与随访检测之间的平均时间为1.02±0.5年。清除组的活动性和慢性炎症评分显著降低。在未清除组，活动性评分无显著差异，但慢性炎症评分显著升高。两组的萎缩性胃炎和肠化生评分均无显著变化。未清除组的幽门螺杆菌感染等级显著降低。
胃大部切除术后幽门螺杆菌感染的自发清除率为38.6%（27/70），发生在较大比例的患者中，且比以往研究发生得更早（1.02±0.5年）。我们建议未来需要对胃大部切除术后幽门螺杆菌感染的自发清除率及其机制进行进一步的前瞻性研究。
