一碳代谢、表观遗传学和叶酸相关疾病中的多态性。
Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies.
作者信息
Stover Patrick J
机构信息
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.
出版信息
J Nutrigenet Nutrigenomics. 2011;4(5):293-305. doi: 10.1159/000334586. Epub 2012 Feb 22.
Abstract
Folate-mediated 1-carbon metabolism is a network of interconnected metabolic pathways necessary for the synthesis of purine nucleotides, thymidylate and the remethylation of homocysteine to methionine. Disruptions in this pathway influence both DNA synthesis and stability and chromatin methylation, and result from nutritional deficiencies and common gene variants. The mechanisms underlying folate-associated pathologies and developmental anomalies have yet to be established. This review focuses on the relationships among folate-mediated 1-carbon metabolism, chromatin methylation and human disease, and the role of gene-nutrient interactions in modifying epigenetic processes.
摘要
叶酸介导的一碳代谢是一个由相互关联的代谢途径组成的网络，对于嘌呤核苷酸、胸苷酸的合成以及同型半胱氨酸再甲基化为甲硫氨酸而言必不可少。该途径的紊乱会影响DNA合成与稳定性以及染色质甲基化，其起因是营养缺乏和常见基因变异。叶酸相关病症和发育异常背后的机制尚未明确。本综述着重探讨叶酸介导的一碳代谢、染色质甲基化与人类疾病之间的关系，以及基因-营养相互作用在改变表观遗传过程中的作用。
相似文献
1
Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies.一碳代谢、表观遗传学和叶酸相关疾病中的多态性。
J Nutrigenet Nutrigenomics. 2011;4(5):293-305. doi: 10.1159/000334586. Epub 2012 Feb 22.
2
A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism.一个数学模型为叶酸介导的一碳代谢的营养和遗传方面提供了见解。
J Nutr. 2006 Oct;136(10):2653-61. doi: 10.1093/jn/136.10.2653.
3
One-carbon metabolism-genome interactions in folate-associated pathologies.叶酸相关疾病中单碳代谢-基因组相互作用。
J Nutr. 2009 Dec;139(12):2402-5. doi: 10.3945/jn.109.113670. Epub 2009 Oct 7.
4
Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor.示踪剂衍生的人体总同型半胱氨酸再甲基化和叶酸依赖性同型半胱氨酸合成速率表明，丝氨酸是主要的一碳供体。
Am J Physiol Endocrinol Metab. 2004 Feb;286(2):E272-9. doi: 10.1152/ajpendo.00351.2003. Epub 2003 Oct 14.
5
Cell cycle regulation of folate-mediated one-carbon metabolism.叶酸介导的一碳代谢的细胞周期调控。
Wiley Interdiscip Rev Syst Biol Med. 2018 Nov;10(6):e1426. doi: 10.1002/wsbm.1426. Epub 2018 Jun 11.
6
Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative Observational Study.叶酸介导的一碳代谢基因及其与营养因素对结直肠癌风险的相互作用：妇女健康倡议观察性研究
Cancer. 2015 Oct 15;121(20):3684-91. doi: 10.1002/cncr.29465. Epub 2015 Jun 24.
7
DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models.DNA 甲基转移酶和去甲基化酶活性受阿尔茨海默病模型中一碳代谢的调节。
J Nutr Biochem. 2011 Mar;22(3):242-51. doi: 10.1016/j.jnutbio.2010.01.010. Epub 2010 Jun 22.
8
Folate-mediated one-carbon metabolism.叶酸介导的一碳代谢。
Vitam Horm. 2008;79:1-44. doi: 10.1016/S0083-6729(08)00401-9.
9
Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).甘氨酸N-甲基转移酶（GNMT）和亚甲基四氢叶酸还原酶（MTHFR）对叶酸介导的一碳代谢的调节
J Nutr Sci Vitaminol (Tokyo). 2015;61 Suppl:S148-50. doi: 10.3177/jnsv.61.S148.
10
[Do folates have an impact on fertility?].[叶酸对生育能力有影响吗？]
Gynecol Obstet Fertil. 2008 Sep;36(9):930-9. doi: 10.1016/j.gyobfe.2008.07.004. Epub 2008 Aug 12.
引用本文的文献
1
Targeting Divergent Pathways in the Nutritional Management of Depression.靶向抑郁症营养管理中的不同途径。
Nutrients. 2024 Aug 22;16(16):2806. doi: 10.3390/nu16162806.
2
Vitamin B12 supplementation during pregnancy for maternal and child health outcomes.孕期补充维生素 B12 对母婴健康结局的影响。
Cochrane Database Syst Rev. 2024 Jan 8;1(1):CD013823. doi: 10.1002/14651858.CD013823.pub2.
3
Scientific opinion on the tolerable upper intake level for folate.关于叶酸可耐受最高摄入量的科学意见。
EFSA J. 2023 Nov 13;21(11):e08353. doi: 10.2903/j.efsa.2023.8353. eCollection 2023 Nov.
4
Different Aspects of the Voltammetric Detection of Vitamins: A Review.电化学检测维生素的不同方面：综述。
Biosensors (Basel). 2023 Jun 14;13(6):651. doi: 10.3390/bios13060651.
5
Maternal Epigenetic Dysregulation as a Possible Risk Factor for Neurodevelopmental Disorders.母体表观遗传失调可能是神经发育障碍的一个风险因素。
Genes (Basel). 2023 Feb 25;14(3):585. doi: 10.3390/genes14030585.
6
Periconceptional Mediterranean diet during pregnancy on children's health.孕期地中海饮食对儿童健康的影响。
J Prev Med Hyg. 2022 Oct 17;63(2 Suppl 3):E65-E73. doi: 10.15167/2421-4248/jpmh2022.63.2S3.2748. eCollection 2022 Jun.
7
Association Study between Polymorphisms in DNA Methylation-Related Genes and Testicular Germ Cell Tumor Risk.DNA 甲基化相关基因多态性与睾丸生殖细胞肿瘤风险的关联研究。
Cancer Epidemiol Biomarkers Prev. 2022 Sep 2;31(9):1769-1779. doi: 10.1158/1055-9965.EPI-22-0123.
8
Therapeutic Potential of the Purinergic System in Major Depressive Disorder Associated with COVID-19.嘌呤能系统在 COVID-19 相关重度抑郁症中的治疗潜力。
Cell Mol Neurobiol. 2023 Mar;43(2):621-637. doi: 10.1007/s10571-022-01215-6. Epub 2022 Mar 28.
9
Impaired Folate-Mediated One-Carbon Metabolism in Type 2 Diabetes, Late-Onset Alzheimer's Disease and Long COVID.2 型糖尿病、晚发性阿尔茨海默病和长新冠患者的叶酸介导的一碳代谢受损。
Medicina (Kaunas). 2021 Dec 23;58(1):16. doi: 10.3390/medicina58010016.
10
Provision of folic acid for reducing arsenic toxicity in arsenic-exposed children and adults.为暴露于砷环境中的儿童和成人提供叶酸以减少砷毒性。
Cochrane Database Syst Rev. 2021 Oct 18;10(10):CD012649. doi: 10.1002/14651858.CD012649.pub2.
本文引用的文献
1
Epigenetic Silencing of ALDH1L1, a Metabolic Regulator of Cellular Proliferation, in Cancers.醛脱氢酶1家族成员L1（ALDH1L1）作为细胞增殖的代谢调节因子在癌症中的表观遗传沉默
Genes Cancer. 2011 Feb;2(2):130-9. doi: 10.1177/1947601911405841.
2
Environmental epigenetic transgenerational inheritance and somatic epigenetic mitotic stability.环境表观遗传跨代遗传与体细胞核有丝分裂稳定性
Epigenetics. 2011 Jul;6(7):838-42. doi: 10.4161/epi.6.7.16537. Epub 2011 Jul 1.
3
Folate pathway and nonsyndromic cleft lip and palate.叶酸代谢途径与非综合征性唇腭裂
Birth Defects Res A Clin Mol Teratol. 2011 Jan;91(1):50-60. doi: 10.1002/bdra.20740. Epub 2010 Dec 1.
4
Polymorphisms in folate-metabolizing genes and risk of non-Hodgkin's lymphoma.叶酸代谢基因多态性与非霍奇金淋巴瘤风险。
Leuk Res. 2011 Apr;35(4):508-15. doi: 10.1016/j.leukres.2010.10.004. Epub 2010 Nov 4.
5
Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases.组蛋白甲基化的逆转：组蛋白去甲基化酶的生化和分子机制。
Annu Rev Biochem. 2010;79:155-79. doi: 10.1146/annurev.biochem.78.070907.103946.
6
Genomic imprinting-an epigenetic gene-regulatory model.基因组印记——一种表观遗传基因调控模型。
Curr Opin Genet Dev. 2010 Apr;20(2):164-70. doi: 10.1016/j.gde.2010.01.009. Epub 2010 Feb 12.
7
Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer.甲基代谢酶和表观遗传调控因子的遗传变异：与结直肠癌启动子 CpG 岛过度甲基化的关联。
Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):3086-96. doi: 10.1158/1055-9965.EPI-09-0289. Epub 2009 Oct 20.
8
The logic of the hepatic methionine metabolic cycle.肝脏蛋氨酸代谢循环的逻辑。
Biochim Biophys Acta. 2010 Jan;1804(1):89-96. doi: 10.1016/j.bbapap.2009.10.004. Epub 2009 Oct 13.
9
Folic acid source, usual intake, and folate and vitamin B-12 status in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2006.叶酸来源、通常摄入量以及美国成年人的叶酸和维生素 B12 状况：美国国家健康和营养调查（NHANES）2003-2006 年。
Am J Clin Nutr. 2010 Jan;91(1):64-72. doi: 10.3945/ajcn.2009.28401. Epub 2009 Oct 14.
10
Different histological types of non-small cell lung cancer have distinct folate and DNA methylation levels.不同组织学类型的非小细胞肺癌具有不同的叶酸和 DNA 甲基化水平。
Cancer Sci. 2009 Dec;100(12):2325-30. doi: 10.1111/j.1349-7006.2009.01321.x. Epub 2009 Aug 25.
Zotero 插件