Department of Surgery B, Haemek Medical Center, Afula, Israel.
Cryobiology. 2012 Jun;64(3):235-9. doi: 10.1016/j.cryobiol.2012.02.005. Epub 2012 Feb 14.
To examine whether thermo-perfusion of the bile duct and duodenum may protect these organs during cryoablation of adjacent pancreatic tissue.
Cryoablation of the pancreatic tissue, adjacent to the common bile duct and duodenum was performed in two groups of pigs. In the experimental group, the bile duct and duodenum were protected during the cryo-procedure by intraluminal perfusion of warm saline. In the control group, cryoablation was performed without thermo-protection.
All three animals in the control group developed duodenal perforation and abscesses and died within a week. All the pigs in the experimental group survived and on re-operation 14 days after the first procedure were found to have normal duodenum and bile duct adjacent to the cryoablated pancreatic tissue. Histological examinations confirmed these results.
The present study confirms the feasibility and efficacy of thermo-protection of the duodenum and common bile duct during cryoablation of the head of the pancreas.
研究胆管和十二指肠的热灌注是否可以在冷冻消融毗邻胰腺组织时保护这些器官。
在两组猪中进行胰腺组织的冷冻消融，毗邻胆管和十二指肠。在实验组中，通过腔内温热盐水灌注在冷冻过程中保护胆管和十二指肠。在对照组中，不进行热保护而进行冷冻消融。
对照组的三只动物均发生十二指肠穿孔和脓肿，并在一周内死亡。实验组的所有猪均存活，在第一次手术后 14 天再次手术时，发现冷冻消融的胰腺组织旁的十二指肠和胆管正常。组织学检查证实了这些结果。
本研究证实了在胰腺头部冷冻消融时保护十二指肠和胆总管的可行性和有效性。
