不同序列类型的肺炎克雷伯菌导致 blaNDM-1 在印度、瑞典和英国的传播。
Diverse sequence types of Klebsiella pneumoniae contribute to the dissemination of blaNDM-1 in India, Sweden, and the United Kingdom.
机构信息
Clinical Microbiology L2:02, Karolinska Institutet—MTC, Karolinska University Hospital, Stockholm, Sweden.
出版信息
Antimicrob Agents Chemother. 2012 May;56(5):2735-8. doi: 10.1128/AAC.06142-11. Epub 2012 Feb 21.
Abstract
Clinical isolates of Klebsiella pneumoniae producing NDM-1 carbapenemase from India (n = 22), the United Kingdom (n = 13), and Sweden (n = 4) were subjected to multilocus sequence typing (MLST), automated repetitive sequence-based PCR (rep-PCR), serotyping, virulence gene screening, and plasmid replicon typing. The most frequently detected MLST sequence types (STs) were ST14 (n = 13; all serotype K2), ST11, ST149, ST231, and ST147. The correlation between MLST and automated rep-PCR was excellent. IncA/C was the most frequently detected plasmid replicon type (n = 14). ST14, ST11, and other successful clones may be important for the dissemination of bla(NDM-1).
摘要
从印度（n=22）、英国（n=13）和瑞典（n=4）分离到的产 NDM-1 碳青霉烯酶的肺炎克雷伯菌临床分离株进行多位点序列分型（MLST）、自动化重复序列基元 PCR（rep-PCR）、血清分型、毒力基因筛查和质粒复制子分型。最常检测到的 MLST 序列型（ST）是 ST14（n=13；均为 K2 血清型）、ST11、ST149、ST231 和 ST147。MLST 和自动 rep-PCR 之间的相关性极好。IncA/C 是最常检测到的质粒复制子类型（n=14）。ST14、ST11 和其他成功克隆可能对 bla(NDM-1)的传播很重要。
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