Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Programs, National Institutes of Health, Baltimore, MD 21224, USA.
Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3979-84. doi: 10.1073/pnas.1200506109. Epub 2012 Feb 21.
The default mode network (DMN) in humans has been suggested to support a variety of cognitive functions and has been implicated in an array of neuropsychological disorders. However, its function(s) remains poorly understood. We show that rats possess a DMN that is broadly similar to the DMNs of nonhuman primates and humans. Our data suggest that, despite the distinct evolutionary paths between rodent and primate brain, a well-organized, intrinsically coherent DMN appears to be a fundamental feature in the mammalian brain whose primary functions might be to integrate multimodal sensory and affective information to guide behavior in anticipation of changing environmental contingencies.
人类的默认模式网络 (DMN) 被认为支持多种认知功能，并与一系列神经心理障碍有关。然而，其功能仍不清楚。我们发现，大鼠具有与非人类灵长类动物和人类的 DMN 非常相似的 DMN。我们的数据表明，尽管啮齿动物和灵长类动物的大脑在进化上有明显的差异，但一个组织良好、内在连贯的 DMN 似乎是哺乳动物大脑的一个基本特征，其主要功能可能是整合多模态感觉和情感信息，以引导行为，以适应不断变化的环境。
