Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.
Department of Neuroscience and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Epidemiol Psychiatr Sci. 2020 Sep 8;29:e166. doi: 10.1017/S2045796020000803.
Since its discovery in 1997, the default mode network (DMN) and its components have been extensively studied in both healthy individuals and psychiatric patients. Several studies have investigated possible DMN alterations in specific mental conditions such as bipolar disorder (BD). In this review, we describe current evidence from resting-state functional magnetic resonance imaging studies with the aim to understand possible changes in the functioning of the DMN in BD. Overall, several types of analyses including seed-based and independent component have been conducted on heterogeneous groups of patients highlighting different results. Despite the differences, findings seem to indicate that BD is associated with alterations in both frontal and posterior DMN structures, mainly in the prefrontal, posterior cingulate and inferior parietal cortices. We conclude this review by suggesting possible future research directions.
自 1997 年发现以来，默认模式网络（DMN）及其组成部分已在健康个体和精神疾病患者中得到广泛研究。许多研究调查了特定精神状况（如双相情感障碍（BD））中 DMN 可能的改变。在这篇综述中，我们描述了基于静息态功能磁共振成像研究的现有证据，旨在了解 BD 中 DMN 功能的可能变化。总的来说，对异质患者群体进行了包括种子和独立成分在内的几种类型的分析，突出了不同的结果。尽管存在差异，但研究结果似乎表明，BD 与额侧和后 DMN 结构的改变有关，主要在前额叶、后扣带回和下顶叶皮层。我们通过提出可能的未来研究方向来结束这篇综述。
