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Krüppel 同源物 1 在半变态和全变态物种的昆虫变态中具有保守的抑制功能。

Conserved repressive function of Krüppel homolog 1 on insect metamorphosis in hemimetabolous and holometabolous species.

机构信息

Institut de Biologia Evolutiva (CSIC-UPF), Passeig Martim de la Barceloneta 37 , 08003 Barcelona, Spain.

出版信息

Sci Rep. 2011;1:163. doi: 10.1038/srep00163. Epub 2011 Nov 21.

DOI:10.1038/srep00163
PMID:22355678
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3240953/
Abstract

Insect metamorphosis is regulated by ecdysteroids, which induce molts, and juvenile hormone (JH), which inhibits metamorphic changes. The molecular action of ecdysteroids has been thoroughly studied, but that of JH is poorly understood, with data currently only being available for holometabolous species, like Drosophila melanogaster and Tribolium castaneum. We studied the function of Krüppel homolog 1 (Kr-h1) in Blattella germanica, a hemimetabolous model. Kr-h1 is a Zn finger transcription factor whose function as transductor of the antimetamorphic action of JH has recently been demonstrated in D. melanogaster and T. castaneum. The RNAi experiments reported herein indicated that Kr-h1 transduces the antimetamorphic action of JH also in B. germanica, thereby suggesting that this role is an ancestral condition that has been conserved in insect evolution from hemimetabolous to holometabolous species.

摘要

昆虫变态受蜕皮激素调控，蜕皮激素诱导蜕皮，保幼激素（JH）抑制变态发育。蜕皮激素的分子作用已得到深入研究，但 JH 的作用知之甚少，目前仅在完全变态的物种，如黑腹果蝇和赤拟谷盗中获得数据。我们研究了 Krüppel 同源物 1（Kr-h1）在半变态模式生物德国小蠊中的功能。Kr-h1 是一种锌指转录因子，其作为 JH 抗变态作用的转导子的功能最近在黑腹果蝇和赤拟谷盗中得到证实。本文报道的 RNAi 实验表明，Kr-h1 在德国小蠊中也转导 JH 的抗变态作用，这表明该作用是一个从半变态到完全变态的昆虫进化过程中保守的祖先状态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b70/3240953/825dd51546de/srep00163-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b70/3240953/366ce4d21863/srep00163-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b70/3240953/ffd8209d4aef/srep00163-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b70/3240953/728ccfa58b79/srep00163-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b70/3240953/825dd51546de/srep00163-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b70/3240953/366ce4d21863/srep00163-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b70/3240953/ffd8209d4aef/srep00163-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b70/3240953/728ccfa58b79/srep00163-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b70/3240953/825dd51546de/srep00163-f4.jpg

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