Institute for Hematopathology, 22547 Hamburg, Germany.
Sci Rep. 2012;2:226. doi: 10.1038/srep00226. Epub 2012 Jan 17.
Similarities in morphology and in glandular and squamous differentiation patterns amongst syringomas of the breast nipple and of the skin suggest a common nature, but the origin of nipple syringoma remains undefined. Using triple immunofluorescence analysis, we found that cells immunopositive for basal keratins K5 and 14 undergo differentiation into glandular and squamous cell lineages. Both tumour types expressed K10, indicative of squamous lineage, but there were specific differences in their glandular lineage. In contrast to the breast nipple syringoma, which expressed glandular keratins K8/18/19, syringoma of the skin only expressed the glandular keratin K19. Therefore, syringomas of the breast nipple and of the skin resemble glandular lineages of the breast nipple duct or eccrine duct epithelium, respectively. From these results we conclude that K5/14-positive cells of the breast nipple ducts are the putative cells of origin for syringomas of the nipple, which highlights the organotypic glandular differentiation potential.
乳晕部汗管瘤和皮肤汗管瘤在形态学及腺和鳞状分化模式上具有相似性，提示其具有共同的性质，但乳晕部汗管瘤的起源仍未确定。通过三重免疫荧光分析，我们发现免疫反应性基底角蛋白 K5 和 K14 的细胞向腺和鳞状细胞谱系分化。两种肿瘤类型均表达角蛋白 K10，表明为鳞状谱系，但在其腺谱系中存在特异性差异。与表达腺角蛋白 K8/18/19 的乳晕部汗管瘤不同，皮肤汗管瘤仅表达腺角蛋白 K19。因此，乳晕部汗管瘤和皮肤汗管瘤分别类似于乳晕部乳腺导管或小汗腺导管上皮的腺谱系。根据这些结果，我们得出结论，乳晕部乳腺导管的 K5/14 阳性细胞是乳晕部汗管瘤的潜在起源细胞，这突出了其器官样腺分化潜能。
