Gusterson Barry
Division of Cancer Sciences and Molecular Pathology, University of Glasgow, Western Infirmary (Pathology), Dumbarton Road, Glasgow G11 6NT, Scotland, UK.
Nat Rev Cancer. 2009 Feb;9(2):128-34. doi: 10.1038/nrc2571. Epub 2008 Dec 29.
It has been proposed that gene expression profiles will revolutionize the classification of breast cancer, eventually replacing histopathology with a more reproducible technology. These new approaches, combined with a better understanding of the cellular origins of breast cancer, should enable us to identify patient subgroups for more effective therapy. However, in such a rapidly advancing field it is essential that initial and thought-provoking results do not become established as 'facts' without question. This Opinion addresses some of the negatives and positives generated by the term 'basal-like' breast cancer, and questions its existence as an entity.
有人提出，基因表达谱将彻底改变乳腺癌的分类方式，最终用一种更具可重复性的技术取代组织病理学。这些新方法，再加上对乳腺癌细胞起源的更好理解，应该能使我们识别出患者亚组，从而进行更有效的治疗。然而，在这样一个快速发展的领域，至关重要的是，那些初步的、引人深思的结果不能未经质疑就被确立为“事实”。本观点探讨了“基底样”乳腺癌这一术语所产生的一些消极和积极方面，并质疑其作为一个实体的存在。
