卫生假说：解释胰岛素依赖型糖尿病发病率增高的原因。
The hygiene hypothesis: an explanation for the increased frequency of insulin-dependent diabetes.
机构信息
Université Paris Descartes, 75015 Paris, France; INSERM, Unité 1013, 75015 Paris, France.
出版信息
Cold Spring Harb Perspect Med. 2012 Feb;2(2):a007799. doi: 10.1101/cshperspect.a007799.
Abstract
The steadily increasing frequency of insulin-dependent diabetes in several countries is best explained today by the decline of infections. Epidemiologic and animal data support this conclusion, which, however, requires confirmation by intervention trials in man. The mechanisms of the protective effect of infections on diabetes onset are diverse including competition for homeostatic factors and stimulation of regulatory T cells and of Toll-like receptors. These considerations might have interesting therapeutic applications for the prevention of the disease.
摘要
目前，在一些国家，胰岛素依赖型糖尿病的发病率不断上升，这种现象可以用感染减少来很好地解释。流行病学和动物数据支持这一结论，但这仍需要通过人类干预试验来证实。感染对糖尿病发病的保护作用机制多种多样，包括对稳态因素的竞争和对调节性 T 细胞及 Toll 样受体的刺激。这些考虑因素可能为预防该疾病提供有趣的治疗应用。
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2
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